gms | German Medical Science

64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

26. - 29. Mai 2013, Düsseldorf

Deep brain stimulation of the centromedian parafascicular nucleus alleviates breeding-induced deficient sensorimotor gating in rats

Meeting Abstract

Suche in Medline nach

  • Svilen Angelov - Klinik für Neurosurgery, Medizinische Hochschule Hannover, Hannover, Deutschland
  • Joachim K. Krauss - Klinik für Neurosurgery, Medizinische Hochschule Hannover, Hannover, Deutschland
  • Kerstin Schwabe - Klinik für Neurosurgery, Medizinische Hochschule Hannover, Hannover, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Düsseldorf, 26.-29.05.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. DocMI.04.02

doi: 10.3205/13dgnc302, urn:nbn:de:0183-13dgnc3029

Veröffentlicht: 21. Mai 2013

© 2013 Angelov et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen ( Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.



Objective: In Tourette's syndrome deep brain stimulation (DBS) of the globus pallidus internus (GPi) or of the anterior region of the centromedian parafascicular complex (CM-Pf) have been shown to alleviate tics and associated phenomena possibly related to deficient sensorimotor gating. Breeding-induced deficient prepulse inhibition (PPI) of the acoustic startle response (ASR) has been used as an endophenotype for deficient sensorimotor gating. Recently, we showed that DBS of the rat equivalent of the GPi alleviates breeding-induced deficient PPI. We here investigated whether DBS of the rat CM-Pf would improve breeding-induced deficient sensorimotor gating as well.

Method: Electrodes were stereotaxically implanted bilaterally in the CM-Pf of rats with breeding-induced low and high PPI. After two weeks of recovery, rats were stimulated with 100 µA and 150 µA (130 Hz and 80 µs pulse width), or sham-stimulated with 0 µA for epochs of five days via a cable connected to a stimulator with a swivel interposed to allow free movement of the rats. At the end of each epoch the effect of ongoing stimulation on PPI was tested.

Results: CM-Pf DBS alleviated sensorimotor gating in PPI low rats with 150 µA being more effective than 100 µA. In PPI high rats, stimulation had no effect. ASR was not affected by stimulation in PPI high and low rats. Histological analysis verified appropriate electrode placement in the CM-Pf.

Conclusions: This work indicates an important role of the CM-Pf in the modulation of sensorimotor gating. This model may be useful to further investigate the pathophysiological mechanisms of deficient sensorimotor gating and also the mechanisms of action of DBS in certain neuropsychiatric disorders.