Artikel
Intratumoral convection-enhanced Paclitaxel administration in recurrent gliomas : preliminary results
Intratumorale Administration von Paclitaxel in Rezidivgliomen: erste Ergebnisse
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Autoren
Veröffentlicht: | 4. Mai 2005 |
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Gliederung
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Objective
Recurrent gliomas are an almost universal fatal disease within weeks or months following diagnosís of recurrence. The aim of the present study was to investigate the effect of paclitaxel (Taxol) by way ofintratumoral administered using convection-enhanced delivery in recurrent glioblastomas.
Methods
In 5 patients with recuurent gliomas (glioblastoma or astrocytoma °3) one or two catheters were placed with the aid of Brainlab neuronavigation. Gadolinium was infused over a time period of 24 hours to evaluate the fluid distribution pattern. MR images were made 4, 8 and 24 hours following the starti of the infusion. Following this placlitaxel infusion was administered with a maximum dose of 18mg over a five-day treatment cycle. MR images were made 24 hours later and consecutively every two months following infusion.
Results
Paclitaxel infusion was tolerated well by all patients with no major side effects. In one patient a meningitis occurred, which was successfully treated with antibiotics. Almost immediately following infusion, MR images revealed a significant reduction of the tumor in the areas predetermined by gadolinium infusion.
Conclusions
Paclitaxel infusion is a safe new method in patients with recurrent gliomas. Long-term outcome has to be determined.