Artikel
Comparison of numerical simulated and experimental dye-washout studies in human aneurysms
Vergleich von numerisch simulierten und experimentellen Farbauswaschstudien an menschlichen zerebralen Aneurysmen
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Autoren
Veröffentlicht: | 4. Mai 2005 |
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Gliederung
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Objective
Biofluidmechanical properties such as intraaneurysmal blood pressure, blood flow velocity and wall shear stress influence significantly the development and risk of rupture of cerebral aneurysms. Flow visualization makes the description of clinically important biofluidmechanical findingspossible, that would otherwise not be accessible to visualization. Flow visualization in realistic models of cerebral aneurysms is realized by means of the dye washout method. This method is so expensive that it cannot be applied routinely to real aneurysms. Therefore, we compared numerically simulated dye studies with the dye washout experiments performed in the corresponding silicon models of aneurysms.
Methods
Raw data of human cerebral aneurysms were created by means of conventional CT-angiography or 3D rotational angiography. Three-dimensional geometrical computational models of the aneurysms with inflow and outflow branches were derived. These models were transformed to three-dimensional grids which we used to perform numeric calculations of the bio-fluidmechanical parameters and of dye washout experiments. For the experimental study, a threefold upscaled silicon aneurysmal model was developd. Dye washout experiments were performed using this silicon model.
Results
The calculated spatial distribution of intraaneurysmal blood pressure, flow velocity and wall shear stress is shown for the inflow and outflow branches, and the aneurysm itself. The numerically simulated dye washout corresponds well to dye washout dynamics seen in the silicon models.
Conclusions
Numeric simulation of biofluidmechanical properties of cerebral aneurysms augment our understanding of their biofluidmechanical and clinical behaviour. Numeric simulation can be validated with three-dimensional silicone models. Numeric simulation and the corresponding silicone models allow testing of various therapeutic interventions such as clipping, coiling and stenting.