gms | German Medical Science

24th Annual Meeting of the German Retina Society

German Retina Society

17.06. - 18.06.2011, Aachen

Article

Send article

Influence of the stretching properties of pigmentepithelial detachment (PED) in regard to a rupture in the pigmentepithelium (RIP) during intravitreal anti-VEGF-therapy

Meeting Abstract

Search Medline for

  • Albrecht Lommatzsch - Augenabteilung, St. Franziskus-Hospital Münster
  • B. Lehmann - Augenabteilung, St. Franziskus-Hospital Münster
  • B. Heimes - Augenabteilung, St. Franziskus-Hospital Münster
  • M. Gutfleisch - Augenabteilung, St. Franziskus-Hospital Münster
  • D. Pauleikhoff - Augenabteilung, St. Franziskus-Hospital Münster

German Retina Society. 24th Annual Conference of the German Retina Society. Aachen, 17.-18.06.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. Doc11rg33

doi: 10.3205/11rg33, urn:nbn:de:0183-11rg331

This is the English version of the article.
The German version can be found at: http://www.egms.de/de/meetings/rg2011/11rg33.shtml

Published: June 15, 2011

© 2011 Lommatzsch et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Background: Observations showed that some patients with AMD and PED developed a RIP during an intravitreal anti-VEGF-therapy. Purpose of the study was to make out a criterion for the predictability of the rupture development.

Methods: Two lengths were measured by spectral domain OCT: the basis and the arch of the PED within 11 eyes (6 ♀; 5 ♂; mean age 73.8 years) that showed no RIP before and after anti-VEGF therapy. The pictures have been exported in proportion 1:1 micrometers into the Inskape programme to designate the relative proportion between the length of the PED-basis and the PED-arch through vector analysis. These results have been compared to 12 eyes (7 ♀; 5 ♂; mean age 71.8 years) who developed a RIP while 12 weeks after injection.

Results: Prior to therapy the average of the arc length was 2.74 and of the basislenght 2.57 with a stretchingratio (arc length/basislength) of 1.97. The stretchingratio after 12 weeks averaged 1.04 (p=0.15). In the group of RIP-patients the stretchingratio before and after therapy was marginal significant (0.06).

Conclusions: During the formation of a PED accrues a quantitatively stretching of the RPE, that can also form back. The dimension of the stretching seems to be an issue within the development of a RIP.