gms | German Medical Science

23rd Annual Meeting of the German Retina Society

German Retina Society

24.09. - 25.09.2010, Freiburg

Ocular mediators of inflammation and neovascularization in retinal vein occlusion and diabetic retinopathy

Meeting Abstract

  • Bastian Grundel - University Eye Clinic Freiburg i. Br.
  • D. Michels - University Eye Clinic Freiburg i. Br.
  • G. Martin - University Eye Clinic Freiburg i. Br.
  • H. Agostini - University Eye Clinic Freiburg i. Br.

German Retina Society. 23rd Annual Conference of the German Retina Society. Freiburg i. Br., 24.-25.09.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. Doc10rg73

doi: 10.3205/10rg73, urn:nbn:de:0183-10rg738

This is the translated version of the article.
The original version can be found at: http://www.egms.de/de/meetings/rg2010/10rg73.shtml

Published: September 21, 2010

© 2010 Grundel et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

Text

Background: Vitreous samples from patients with retinal vein occlusion showed changes in the concentration of the proteins CCL7, PPBP, CXCL11, ADIPOQ, OPG, TNFRSF18, IL18BP, and VEGFA165b compared to the control group (macular hole, macular pucker). This raised the questions whether these proteins are expressed in ocular tissue and whether they are characteristic of vein occlusion.

Methods: The expression patterns were investigated by immunohistochemistry on specimens with diagnosis for retinal vein occlusion or diabetic retinopathy.

Results: The proteins CCL7, CXCL11, ADIPOQ, OPG, IL18BP, and VEGFA165b were produced by different cells in ocular tissue. In contrast, PPBP and TNFRSF18 were detected in serum only. Obviously, they are expressed anywhere else and transported to the eye in a second step. No differences between eyes from patients with retinal vein occlusion or diabetic retinopathy were found.

Conclusion: The investigated proteins are general mediators of inflammation and neovascularization. Predominantly, they are produced by ocular tissues indicating local inflammation. They are not specific for retinal vein occlusion, although they are expressed at higher levels in this condition.