gms | German Medical Science

29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Hochdruckliga e. V. DHL ® - Deutsche Hypertonie Gesellschaft Deutsches Kompetenzzentrum Bluthochdruck

23. bis 25.11.2005, Berlin

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Angiotensin-converting enzyme 2 gene A/G single nucleotide polymorphism is associated with hypertension in Chinese patients with metabolic syndrome

Angiotensin-converting enzyme 2 Polymorphismus bei chinesischen Patienten mit metabolischem Syndrom

Meeting Abstract

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  • presenting/speaker M. Tepel - Charité - Campus Benjamin Franklin Berlin (Berlin, D)
  • presenting/speaker J. Zhong - Department of Hypertension and Endocrinology Chongqing (PR China)
  • presenting/speaker Z. Zhu - Department of Hypertension and Endocrinology Chongqing (PR China)
  • presenting/speaker Z. Yan - Department of Hypertension and Endocrinology Chongqing (PR China)
  • presenting/speaker D. Liv - Department of Hypertension and Endocrinology Chongqing (PR China)
  • presenting/speaker X. Nia - Department of Hypertension and Endocrinology Chongqing (PR China)

Hypertonie 2005. 29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Berlin, 23.-25.11.2005. Düsseldorf, Köln: German Medical Science; 2006. Doc05hochP24

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hoch2005/05hoch024.shtml

Published: August 8, 2006

© 2006 Tepel et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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We investigated whether angiotensin-converting enzyme 2 (ACE2) gene A/G single nucleotide polymorphism is associated with hypertension in Chinese patients with metabolic syndrome. The study was conducted in 353 patients with metabolic syndrome. The alleles of the ACE2 A/G polymorphism, which is located on the X chromosome, were detected using polymerase chain reaction and subsequent cleavage by Alu I restriction endonuclease. G allele frequencies in patients with metabolic syndrome were 36.6% in female subjects and 43.4% in male subjects, respectively. Female patients with metabolic syndrome who carry GG genotype had a significantly higher diastolic blood pressure compared with other genotypes. Multivariate logistic regression showed that female gender (p = 0.019) and carrying only the G allele (odds ratio 2.83 [95% CI 1.36 to 5.91]; p = 0.005) were significantly associated with increased diastolic blood pressure. It is concluded that the ACE2 A/G polymorphism is associated with hypertension in patients with metabolic syndrome.