gms | German Medical Science

29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Hochdruckliga e. V. DHL ® - Deutsche Hypertonie Gesellschaft Deutsches Kompetenzzentrum Bluthochdruck

23. bis 25.11.2005, Berlin

Angiotensin-converting enzyme 2 gene A/G single nucleotide polymorphism is associated with hypertension in Chinese patients with metabolic syndrome

Angiotensin-converting enzyme 2 Polymorphismus bei chinesischen Patienten mit metabolischem Syndrom

Meeting Abstract

Suche in Medline nach

  • presenting/speaker M. Tepel - Charité - Campus Benjamin Franklin Berlin (Berlin, D)
  • presenting/speaker J. Zhong - Department of Hypertension and Endocrinology Chongqing (PR China)
  • presenting/speaker Z. Zhu - Department of Hypertension and Endocrinology Chongqing (PR China)
  • presenting/speaker Z. Yan - Department of Hypertension and Endocrinology Chongqing (PR China)
  • presenting/speaker D. Liv - Department of Hypertension and Endocrinology Chongqing (PR China)
  • presenting/speaker X. Nia - Department of Hypertension and Endocrinology Chongqing (PR China)

Hypertonie 2005. 29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Berlin, 23.-25.11.2005. Düsseldorf, Köln: German Medical Science; 2006. Doc05hochP24

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hoch2005/05hoch024.shtml

Veröffentlicht: 8. August 2006

© 2006 Tepel et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

We investigated whether angiotensin-converting enzyme 2 (ACE2) gene A/G single nucleotide polymorphism is associated with hypertension in Chinese patients with metabolic syndrome. The study was conducted in 353 patients with metabolic syndrome. The alleles of the ACE2 A/G polymorphism, which is located on the X chromosome, were detected using polymerase chain reaction and subsequent cleavage by Alu I restriction endonuclease. G allele frequencies in patients with metabolic syndrome were 36.6% in female subjects and 43.4% in male subjects, respectively. Female patients with metabolic syndrome who carry GG genotype had a significantly higher diastolic blood pressure compared with other genotypes. Multivariate logistic regression showed that female gender (p = 0.019) and carrying only the G allele (odds ratio 2.83 [95% CI 1.36 to 5.91]; p = 0.005) were significantly associated with increased diastolic blood pressure. It is concluded that the ACE2 A/G polymorphism is associated with hypertension in patients with metabolic syndrome.