gms | German Medical Science

27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Liga zur Bekämpfung des hohen Blutdrucks – Deutsche Hypertonie Gesellschaft e. V.

26. bis 29.11.2003, Bonn

Estimation of the spontaneous baroreceptor sensitivity with latency

Bestimmung des spontanen Baroreflexes mit verzögerten Herzfrequenzreaktionen

Meeting Abstract (Hypertonie 2003)

  • presenting/speaker H. Malberg
  • N. Wessel
  • R. Bauernschmitt

Hypertonie 2003. 27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Bonn, 26.-29.11.2003. Düsseldorf, Köln: German Medical Science; 2004. Doc03hochP48

The electronic version of this article is the complete one and can be found online at:

Published: November 11, 2004

© 2004 Malberg et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Baroreflex sensitivity (BRS) is a very important parameter for risk stratification, particularly in patients who suffer from myocardial infarction. This study is aimed at investigating the latency in spontaneous baroreflex control of patients with dilated cardiomyopathy (DCM) in comparison to healthy subjects.

Non-invasive, continuous blood pressure curves were recorded over 30 min for 31 DCM patients (EF=28.2±9.3%, NYHA class II-III) and 151 control subjects. From the signals, the heart rate (HR) and the systolic blood pressure (SBP) were extracted.

New mechanisms to estimate the dynamic reflection of the heart rate on consecutive slopes in systolic blood pressure were integrated in the Dual Sequence Method (DSM). In this way, the bradycardic and tachycardic baroreflex (BR) slopes could be calculated for synchronous, delayed (lag of 3 heart beats), and dynamic (maximal slope up to 15 beats after alteration in SBP) fluctuations in heart rate.

The results show highly significant differences in baroreflex control between DCM patients and controls.

[Tab. 1]

The assessment of the latency of reflecting alterations in HR following SBP fluctuations allows a more detailed analysis of BR control. Based on DSM, the tachycardic average slope showed a highly signifi-cant reduction when applying lag 3 to synchronous BR slopes in patients with DCM compared to con-trols. This parameter may explain the different velocity of vagal and sympathetic BR control. The DCM patients showed a faster, but apparently less effective BR regulation on higher alterations in SBP.