gms | German Medical Science

77th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

24.05. - 28.05.2006, Mannheim

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TIL activity and RCAS1 expression in head and neck cancer and its healthy stroma

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  • corresponding author Magdalena Dutsch-Wicherek - HNO Klinik, Jagiellonische Universität, Krakau, Polen
  • Romana Tomaszewska - Klinik für Pathologie, Jagiellonische Universität, Krakau, Polen
  • Eugeniusz Olszewski - HNO Klinik, Jagiellonische Universität, Krakau, Polen
  • Jacek Skladzien - HNO Klinik, Jagiellonische Universität, Krakau, Polen
  • Tadeusz J. Popiela - Klinik für Chirurgie, Jagiellonische Universität, Krakau, Polen
  • Maciej Modrzejewski - HNO Klinik Jagiellonisches Universität, Krakau, Polen

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 77. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.. Mannheim, 24.-28.05.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06hnod707

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hnod2006/06hnod707.shtml

Published: April 24, 2006

© 2006 Dutsch-Wicherek et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

RCAS1 is responsible for avoiding recognition of cancer cells by immune cells, acts as a ligand for a putative receptor expressed on immune cells including T, B lymphocytes and NK cells. It is not only a poor prognostic factor but also is thought to regulate the immune cytotoxic activity. The aim of our study was to evaluate the expression of RCAS1 and CD69 characteristic for mononuclear immune cells activity in head and neck cancer and in its healthy stroma.

Materials and Methods: We have sampled 60 tissue samples: 30 derived from head and neck squamous cell carcinoma, 30 from clear surgical margins of these tumors. RCAS1 and CD 69 expression were assessed using immunohistochemistry method.

Results: RCAS1 expression was revealed in all neoplasmatic tissue samples and in all histopathologically healthy surgical margins. High RCAS1 expression in cancer and clear surgical margin was connected with the presence of lymph node metastases, the extracapsular spread and low cancer differentiation. RCAS1 expression in clear surgical margin correlated with CD69 expression in N0 tumors, this correlation was not observed in N1, N2 tumors.

Conclusions: The integrity of tumor environment is preserved in tumors without local or systemic spread by many factors including RCAS1 regulating the cytotoxic activity, in spreading tumors this regulation seems to be disturbed. The presented results seem to confirm the participation of tumor environment in tumor progression.