gms | German Medical Science

76th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

04.05. - 08.05.2005, Erfurt

Allergy-associated receptor eotaxin-2 and ist receptor CCR-3 : differentiation between normal and polypous nasal mucosa

Meeting Abstract

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  • corresponding author Rebekka Pods - ENT, Hospital of Schwerin, Schwerin
  • Dirk Schaefer - ENT, University Mannheim, Mannheim
  • Steffen Maune - ENT, University Kiel, Kiel

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 76. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.. Erfurt, 04.-08.05.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc05hno542

The electronic version of this article is the complete one and can be found online at:

Published: September 22, 2005

© 2005 Pods et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Chronic-polypous sinusitis is often associated with an eosinophilia of nasal tissue. CC-chemokines like RANTES, MCP or eotaxin are well known as chemotactic mediators of eosinophilic granulocytes. All of the use CCR-3 as their receptor. The aim of this study was to differentiate the mediator- and receptor-expression of normal and polypous nasal mucosa. Biopsies of nasal turbinates and polypous tissue were immunhistochemical characterised using anti-eotaxin-2- and anti-CCR-3-antibodies. In epithelial and endothelial cells there was only a low evidence of eotaxin-2, whereas there was a high evidence in polypous tissue. CCR-3-positive cells were rarely verified in nasal polypous mucosa. Positive cells were characterised as eosinophilic granulocytes and lymphocytes.

Endothelial and epithelial cells are a possible source of eotaxin-2 in normal nasal mucosa and in nasal polyps. These allergen-activated cells synthesize chemokines, followed by a expression of CCR-3. CCR-3-antagonists could be a therapeutic possibility in inflammatory and allergic diseases in future.