gms | German Medical Science

104th DOG Annual Meeting

21. - 24.09.2006, Berlin

Reliability of dosing, ease of administration and daily costs in glaucoma combination therapy in Germany, Switzerland, UK and Ireland

Meeting Abstract

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  • A. P. Buchholz - Diakonissenkrankenhaus Karlsruhe-Rüppurr, Augenabteilung, Karlsruhe, Germany
  • M. Tan - Städtisches Klinikum Karlsruhe, Augenklinik, Karlsruhe, Germany

Deutsche Ophthalmologische Gesellschaft e.V.. 104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft (DOG). Berlin, 21.-24.09.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06dogP294

The electronic version of this article is the complete one and can be found online at:

Published: September 18, 2006

© 2006 Buchholz et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




To assess ease of use, dosing reliability and daily treatment costs with currently existing fixed combination therapies.


Three ophthalmologists and 1 elderly patient were asked to evaluate use of Cosopt, Xalacom and Combigan. They performed drop count and rated product handling. Daily treatment costs were then compared in 4 countries, including Germany.


All bottles were sufficient for 1 month of treatment. Least variability in drop numbers was found for Combigan. Handling of the Cosopt bottle was found to be most difficult. Daily treatment costs were highest for Xalacom.


These findings suggest that Combigan has the highest dosing reliability overall. Combigan also has lowest daily costs in two countries. Xalacom costs were highest in all 4 countries.