gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Evidence-based medical therapy of postoperative endophthalmitis

Meeting Abstract

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  • corresponding author W. Behrens-Baumann - University Eye Hospital Magdeburg
  • corresponding author Expert commission "Endophthalmitis" - University Eye Hospital Magdeburg

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogFR.15.05

The electronic version of this article is the complete one and can be found online at:

Published: September 22, 2004

© 2004 Behrens-Baumann et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




The globe-threatening condition of postoperative endophthalmitis is a therapeutic challenge for the involved physician. Besides surgical intervention, medical therapy has been suggested and discussed as a therapeutic alternative.


A meta-analysis of all studies and reports on medical therapy of postoperative endophthalmitis was performed by the expert commission employing the Medline and PubMed databases.


The Early Vitrectomy Study (EVS) is the only prospective randomized study addressing medical therapy of postoperative endophthalmitis. Due to its unsuitable study design, it does not answer the question of the optimal antiinfective drug regimen. Some valid results of different studies allow the conclusion that vancomycin is the most suitable agent for the treatment of grampositive pathogens and ceftacidime for gramnegative pathogens. Simultaneous application of systemic steroids is suggested to be useful.


So far, no prospective randomized studies on the medical therapy of postoperative endophthalmitis have been conducted. However, according to validated data of different studies, a combination therapy with different agents is advisable.