gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Evidence-based medical therapy of postoperative endophthalmitis

Meeting Abstract

Suche in Medline nach

  • corresponding author W. Behrens-Baumann - University Eye Hospital Magdeburg
  • corresponding author Expert commission "Endophthalmitis" - University Eye Hospital Magdeburg

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogFR.15.05

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dog2004/04dog295.shtml

Veröffentlicht: 22. September 2004

© 2004 Behrens-Baumann et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

The globe-threatening condition of postoperative endophthalmitis is a therapeutic challenge for the involved physician. Besides surgical intervention, medical therapy has been suggested and discussed as a therapeutic alternative.

Methods

A meta-analysis of all studies and reports on medical therapy of postoperative endophthalmitis was performed by the expert commission employing the Medline and PubMed databases.

Results

The Early Vitrectomy Study (EVS) is the only prospective randomized study addressing medical therapy of postoperative endophthalmitis. Due to its unsuitable study design, it does not answer the question of the optimal antiinfective drug regimen. Some valid results of different studies allow the conclusion that vancomycin is the most suitable agent for the treatment of grampositive pathogens and ceftacidime for gramnegative pathogens. Simultaneous application of systemic steroids is suggested to be useful.

Conclusions

So far, no prospective randomized studies on the medical therapy of postoperative endophthalmitis have been conducted. However, according to validated data of different studies, a combination therapy with different agents is advisable.