gms | German Medical Science

Deutscher Kongress für Orthopädie und Unfallchirurgie
74. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie
96. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie
51. Tagung des Berufsverbandes der Fachärzte für Orthopädie und Unfallchirurgie

26. - 29.10.2010, Berlin

Positive effect of an autologous platelet concentrate in lateral epicondylitis – A double-blind randomized controlled trial: PRP versus corticosteroid injection with a 1 year follow-up

Meeting Abstract

  • T. Gosens - St Elisabeth Hospital Tilburg, Orthopaedics and Traumatology, Tilburg, Netherlands
  • J. Peerbooms - St Elisabeth Hospital Tilburg, Orthopaedics and Traumatology, Tilburg, Netherlands
  • J. Sluimer - St Elisabeth Hospital Tilburg, Orthopaedics and Traumatology, Tilburg, Netherlands
  • J. Bruijn - St Elisabeth Hospital Tilburg, Orthopaedics and Traumatology, Tilburg, Netherlands

Deutscher Kongress für Orthopädie und Unfallchirurgie. 74. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 96. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 51. Tagung des Berufsverbandes der Fachärzte für Orthopädie. Berlin, 26.-29.10.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. DocIN23-121

DOI: 10.3205/10dkou142, URN: urn:nbn:de:0183-10dkou1429

Published: October 21, 2010

© 2010 Gosens et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

Text

Objective: Platelet Rich Plasma (PRP) has shown to be a general stimulation for repair.

To determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis.

Trial registration: ClinicalTrials.gov. Identifier: 2007-004947-31. http://www.clinicaltrials.gov

Methods: A double blind randomized controlled trial with a one-year follow-up between May 2006 and January 2008.

The trial was conducted in two teaching hospitals in The Netherlands.

100 patients with chronic lateral epicondylitis were randomly assigned in the PRP group (n=51) or in the corticosteroid group (n=49). Randomization and allocation to the trial group were carried out by a central computer system.

Patients were randomized to receive either a corticosteroid injection or an autologous platelet concentrate injection through a peppering needling technique.

The primary analysis included VAS and DASH scores.

Results and conclusions: Successful treatment was defined as more than a 25% reduction in VAS or DASH score without a reintervention after 1 year. The results showed that 24 of the 49 patients (49%) in the corticosteroid group and 37 of the 51 patients (73%) in the PRP group were defined as successful with the VAS score, which was significantly different (P<0,001). 25 of the 49 patients (51%) in the corticosteroid group and 37 of the 51 patients (73%) patients in the PRP group were defined as successful with the DASH, which was also significantly different (P=0,005). The corticosteroid group was actually better initially and then declined, while the PRP group progressively improved.

Treatment of patients with chronic lateral epicondylitis with PRP reduces pain and increases function significantly, exceeding the effect of corticosteroid injection. Future decisions for application of the PRP for lateral epicondylitis should be confirmed by further follow-up from this trial and should take into account possible costs and harms as well as benefits.