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65th Annual Meeting of the German Society of Neurosurgery (DGNC)

German Society of Neurosurgery (DGNC)

11 - 14 May 2014, Dresden

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68Ga-DOTATATE-PET imaging in spinal meningeoma – Case report

Meeting Abstract

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  • Philipp Jörg Slotty - Neurochirurgische Klinik, Heinrich-Heine-Universität Düsseldorf, Deutschland
  • Sebastian A. Ahmadi - Neurochirurgische Klinik, Heinrich-Heine-Universität Düsseldorf, Deutschland
  • F. F. Behrendt - Klinik für Nuklearmedizin, Universitätsklinikum der RWTH Aachen, Deutschland
  • Karl-Josef Langen - Klinik für Nuklearmedizin, Universitätsklinikum der RWTH Aachen, Deutschland; Institut für Neurowissenschaften und Medizin (INM-4), Forschungszentrum Jülich, Jülich, Deutschland
  • Jan F. Cornelius - Neurochirurgische Klinik, Heinrich-Heine-Universität Düsseldorf, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Dresden, 11.-14.05.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. DocP 192

doi: 10.3205/14dgnc586, urn:nbn:de:0183-14dgnc5865

Published: May 13, 2014

© 2014 Slotty et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective: Imaging with positron emission tomography and 68Ga-DOTA peptides is a promising method in intracranial meningiomas. Especially in recurrent meningioma discrimination between scar tissue and recurrent tumor tissue in MRI is often difficult. We report the first case of 68Ga-DOTATATE-PET/CT imaging in recurrent spinal meningioma.

Method: A 64-year-old Caucasian female patient was referred to our department with the second recurrence of thoracic meningothelial meningioma. In MRI imaging it remained unclear if the multiple enhancements seen represented scar tissue or vital tumor. We offered 68Ga-DOTATATE-PET/CT imaging in order to evaluate the best strategy.

Results: 68Ga-DOTATATE-PET/CT imaging revealed strong tracer uptake in parts of the lesions. The pattern did distinctly differ from MRI enhancement. Multiple biopsies were performed in the PET-positive and PET-negative regions. Histological results confirmed the prediction of 68Ga-DOTATATE-PET with vital tumor in PET-positive regions and scar tissue in PET-negative regions.

Conclusions: Differentiating scar tissue from tumor may be challenging in recurrent spinal meningioma with MRI alone. In the presented case 68Ga-DOTATATE-PET imaging was able to differentiate non-invasively between tumor and scar.