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65th Annual Meeting of the German Society of Neurosurgery (DGNC)

German Society of Neurosurgery (DGNC)

11 - 14 May 2014, Dresden

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Is Obesity associated with poorer outcome in glioblastoma patients?

Meeting Abstract

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  • Ági Oszvald - Klinik für Neurochirurgie, Universitätsklinikum der Rheinischen-Friedrich-Wilhelms Universität Bonn, Bonn
  • Konstantinos Gousias - Klinik für Neurochirurgie, Universitätsklinikum der Rheinischen-Friedrich-Wilhelms Universität Bonn, Bonn
  • Felix Lehmann - Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum der Rheinischen-Friedrich-Wilhelms Universität Bonn, Bonn
  • Alexis Hadjiathanasiou - Klinik für Neurochirurgie, Universitätsklinikum der Rheinischen-Friedrich-Wilhelms Universität Bonn, Bonn
  • Hartmut Vatter - Klinik für Neurochirurgie, Universitätsklinikum der Rheinischen-Friedrich-Wilhelms Universität Bonn, Bonn
  • Erdem Güresir - Klinik für Neurochirurgie, Universitätsklinikum der Rheinischen-Friedrich-Wilhelms Universität Bonn, Bonn

Deutsche Gesellschaft für Neurochirurgie. 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Dresden, 11.-14.05.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. DocP 034

doi: 10.3205/14dgnc429, urn:nbn:de:0183-14dgnc4290

Published: May 13, 2014

© 2014 Oszvald et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective: Higher Body Mass Index (BMI) has been associated with higher risk of poor outcome in various cancers and is linked to a higher risk of cardiovascular complications. However, the influence of the initial bodyweight on patients with glioblastoma is unclear. Therefore we analyzed outcome, complications and overall survival in glioblatoma patients.

Method: We analyzed 471 consecutive patients (258 men / 213 women) in a single center institute. BMI was assesed at the time of the first surgery and was classified according to the WHO grading (normal weight <25, overweight 25-30, obese >30). The data was collected from January 2006 to December 2011. We included the following parameters: progressionfree survival, overall survival, postoperative complications (symptomatic bleeding, new neurological deficits, ischemia, infeciton, TVT/LE), hospital stay/ICUstay, extent of resection according to 72h postoperative MRI and pre/post operative KPS.

Results: The BMI did not influence the overall survival of all glioblastoma patients. None of the other parameters assessed were influenced by the BMI. Focusing on different complications, the infection rate was significantly (12/471) lower in the overweight patient group, compared to the normal weight and obese glioblastoma patients. The extent of the resection was distributed equally among the three BMI groups. The length of the hospital stay was related to complications, but not to the BMI.

Conclusions: Obese Glioblastoma patients per se do not have a poorer outcome or higher complication rates according to this single center study. Interestingly, overweight patients had significantly lower postoperative infection rates compared to normal weight and obese patients.