Article
Navigated transcranial magnetic stimulation improves the treatment outcome in patients with tumors in presumed motor eloquent location
Search Medline for
Authors
Published: | May 13, 2014 |
---|
Outline
Text
Objective: Navigated transcranial magnetic stimulation (nTMS) enables delineation of resectable versus non-resectable cortical tissue in motor areas. This study examines the treatment of centrally located tumours during two consecutive periods in the same department –the first without and the second with the use of nTMS.
Method: To study the impact of nTMS on the treatment we examined 250 consecutive patients and compared the functional and oncological outcome to a matched pre-TMS control group (n = 115).
Results: nTMS depiction of the primary motor cortex was in accordance with the intraoperative stimulation brain mapping (ISM) in all cases. The nTMS mapping results falsified the suspected involvement of the primary motor cortex in 21.5% of the cases and led to the planning of a more extensive resection in 35.2% and to a more restrictive resection in 3.5% of the cases. In comparison to the control group the addition of nTMS led to a reduction of postoperative deficits from 9.5% to 7.5% and to an increased rate of gross total resections from 78% to 95%. The progression free survival for low-grade/malignant glioma was significantly better in the nTMS group with 28.5/15.5 month than in the control group with 15.4/12.4 months.
Conclusions: nTMS enables more extensive resection of tumours involving essential motor areas and leads to improved neurological outcome and prolonged progression free survival.