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65th Annual Meeting of the German Society of Neurosurgery (DGNC)

German Society of Neurosurgery (DGNC)

11 - 14 May 2014, Dresden

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Comparison of treatment choices in rats formed spinal infection related to implant

Meeting Abstract

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  • Orhan Kalemci - Dokuz Eylul Universtiy, School of Medicine, Department of Neurosurgery
  • Cem Ergon - Dokuz Eylul University School of Medicine, Department of Infectious Disease and Clinical Microbiology
  • Mine Doluca Dereli - Dokuz Eylul University School of Medicine, Department of Infectious Disease and Clinical Microbiology
  • Nurullah Yüceer - Katip Celebi Universtiy, School of Medicine, Department of Neurosurgery
  • Nuri M. Arda - Dokuz Eylul Universtiy, School of Medicine, Department of Neurosurgery
  • Necati Gökmen - Dokuz Eylul University, School of Medicine, Department of Anesthesiology and Reanimation

Deutsche Gesellschaft für Neurochirurgie. 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Dresden, 11.-14.05.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. DocDI.13.07

doi: 10.3205/14dgnc192, urn:nbn:de:0183-14dgnc1928

Published: May 13, 2014

© 2014 Kalemci et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective: After constitution spinal implant infection in rats we want to compare antibiotic, irrigation and removal of implant if are effective for the Treatment.

Method: Wistar strain 40 albino female rats applied to the lumbar 5 laminectomy laminectomy site titanium implants placed 10 8 CFU / 1 cc of Methicillin-Resistant Staphylococcus aureus (MRSA) strains were inoculated animals into five groups were separated. As a group of eight rats preliminary study evaluated only the first infection was created. One of the other four groups as control group while trying the other groups only antibiotics, antibiotic treatment with antibiotics, irrigation and implants were removed. A week later, the rats were sacrificed and tissue samples were obtained from the microbiological examination was performed.

Results: All the tissue examples studied by calculation number of bacteria as CFU / gr. Results are compared by Kruskal-Wallis variance analysis and Mann-Whitney-test. When we compare the treatments with the control group we found that all the treatments were effective.

Conclusions: When the treatment results are compared with the control group we found that statistically most significant treatment is reoperation to remove the implant (p=0.02). But in comparison of treatments we found no difference in between.