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65th Annual Meeting of the German Society of Neurosurgery (DGNC)

German Society of Neurosurgery (DGNC)

11 - 14 May 2014, Dresden

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Impact of intraoperative imaging modalities on overall survival of patients following GTR of brain metastases

Meeting Abstract

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  • Marian C. Neidert - Klinik für Neurochirurgie, UniversitätsSpital Zürich, Schweiz
  • Isabel Hostettler - Klinik für Neurochirurgie, UniversitätsSpital Zürich, Schweiz
  • Jan-Karl Burkhardt - Klinik für Neurochirurgie, UniversitätsSpital Zürich, Schweiz
  • Malte E. Mohme - Klinik für Neurochirurgie, UniversitätsSpital Zürich, Schweiz
  • Ulrike Held - Horten Centre, UniversitätsSpital Zürich, Schweiz
  • Reto Kofmehl - Horten Centre, UniversitätsSpital Zürich, Schweiz
  • Christoph M. Woernle - Klinik für Neurochirurgie, UniversitätsSpital Zürich, Schweiz
  • Luca Regli - Klinik für Neurochirurgie, UniversitätsSpital Zürich, Schweiz
  • Oliver Bozinov - Klinik für Neurochirurgie, UniversitätsSpital Zürich, Schweiz

Deutsche Gesellschaft für Neurochirurgie. 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Dresden, 11.-14.05.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. DocMO.09.06

doi: 10.3205/14dgnc049, urn:nbn:de:0183-14dgnc0494

Published: May 13, 2014

© 2014 Neidert et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective: To analyze the impact of intraoperative resection control modalities on overall survival (OS) and tumor recurrence in 3-months postoperative magnetic resonance imaging (MRI) following gross-total resection (GTR) of brain metastases.

Method: Medical charts of 116 consecutive patients (68f, mean age 59.3±12.9 years) operated between 2009 and 2012 were included in case GTR was achieved as evaluated by the early postoperative high-field MRI. Intraoperative resection control modalities comprised intraoperative ultrasound (ioUS, n=64), intraoperative low-field MRI (ioMRI, n=13), neither modality (n=35), and a group with a combination of ioUS and ioMRI (n=4). The endpoint of our study was overall survival (OS) – analyzed in a Kaplan-Meier-Plot and a Cox-Proportional-Hazards-Model. The secondary endpoint was tumor recurrence after 3 months.

Results: In a multivariate Cox-Model comparing OS between the intraoperative resection control modalities (adjusted for gender, age, preOP Karnofsky) no statistically significant signal was found. Also, no significant difference between the groups was found regarding the rate of tumor recurrence at 3 months.

Conclusions: There is neither a significant difference in OS nor in tumor recurrence at 3 months between the analyzed intraoperative resection control modalities.