gms | German Medical Science

61st Annual Meeting of the German Society of Neurosurgery (DGNC) as part of the Neurowoche 2010
Joint Meeting with the Brazilian Society of Neurosurgery on the 20 September 2010

German Society of Neurosurgery (DGNC)

21 - 25 September 2010, Mannheim

Insertion/deletion polymorphism in the promoter of NFκB1 is associated with the initiation of cerebral aneurysms

Meeting Abstract

  • I. Erol Sandalcioglu - Neurochirurgische Klinik, Universitätsklinikum Essen, Deutschland
  • Michael Adamzik - Klinik für Anästhesiologie, Universitätsklinikum Essen, Deutschland
  • Yuan Zhu - Neurochirurgische Klinik, Universitätsklinikum Essen, Deutschland
  • Winfried Siffert - Institut für Pharmakogenetik, Universitätsklinikum Essen, Deutschland
  • Ulrich Sure - Neurochirurgische Klinik, Universitätsklinikum Essen, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010. Mannheim, 21.-25.09.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. DocP1840

DOI: 10.3205/10dgnc311, URN: urn:nbn:de:0183-10dgnc3113

Published: September 16, 2010

© 2010 Sandalcioglu et al.
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Outline

Text

Objective: NF-κB was shown to play a role as key regulator in the initiation of cerebral aneurysm (CA) formation by active participation of macrophage-mediated chronic inflammatory response. As the insertion/deletion polymorphism in the promoter of NFKB1 proved to influence the severity of inflammatory processes, we investigated whether this polymorphism is associated with CA formation.

Methods: A total of 165 patients with CA (88 patients with ruptured and 77 with non-ruptured CA) and 243 controls were enrolled in this study. All patients and controls were genotyped for the insertion/deletion polymorphism in the promoter of NFκB1 (–94ins/delATTG).

Results: In patients with CA genotypes differed significantly compared to the controls. Patients with CA showed a significantly higher frequency of homozygote (DD) and heterozygote (ID) insertion/deletions polymorphism (p=0.04). Likewise, the frequency of the D allele was significantly higher in the patient group (p=0.04). We found no differences between patients with or without rupture of the CA.

Conclusions: The insertion/deletion polymorphism in the promoter of NFκB1 seems to play a crucial role in the initiation of CA formation, but does not influence the risk of aneurysm rupture.