Artikel
Insertion/deletion polymorphism in the promoter of NFκB1 is associated with the initiation of cerebral aneurysms
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Veröffentlicht: | 16. September 2010 |
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Objective: NF-κB was shown to play a role as key regulator in the initiation of cerebral aneurysm (CA) formation by active participation of macrophage-mediated chronic inflammatory response. As the insertion/deletion polymorphism in the promoter of NFKB1 proved to influence the severity of inflammatory processes, we investigated whether this polymorphism is associated with CA formation.
Methods: A total of 165 patients with CA (88 patients with ruptured and 77 with non-ruptured CA) and 243 controls were enrolled in this study. All patients and controls were genotyped for the insertion/deletion polymorphism in the promoter of NFκB1 (–94ins/delATTG).
Results: In patients with CA genotypes differed significantly compared to the controls. Patients with CA showed a significantly higher frequency of homozygote (DD) and heterozygote (ID) insertion/deletions polymorphism (p=0.04). Likewise, the frequency of the D allele was significantly higher in the patient group (p=0.04). We found no differences between patients with or without rupture of the CA.
Conclusions: The insertion/deletion polymorphism in the promoter of NFκB1 seems to play a crucial role in the initiation of CA formation, but does not influence the risk of aneurysm rupture.