gms | German Medical Science

58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

26. bis 29.04.2007, Leipzig

Spinal radiosurgery for tumour associated spinal pain

Spinale Radiochirurgie gegen spinalen Tumorschmerz

Meeting Abstract

  • corresponding author B. Wowra - Europäisches Cyberknife Zentrum München-Großhadern
  • A. Muacevic - Europäisches Cyberknife Zentrum München-Großhadern
  • S. Zausinger - Neurochirurgische Klinik, Klinikum der Universität München
  • J.-C. Tonn - Neurochirurgische Klinik, Klinikum der Universität München

Deutsche Gesellschaft für Neurochirurgie. 58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC). Leipzig, 26.-29.04.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. DocSO.05.07

The electronic version of this article is the complete one and can be found online at:

Published: April 11, 2007

© 2007 Wowra et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: To examine feasibility and short-term efficacy of frame less fiducial free robotic radiosurgery to control tumour associated spinal pain syndromes.

Methods: The CyberknifeTM technology including the X-sightTM software for skeletal structure tracking was used to treat tumours in the vertebral column and spinal cord. Clinical symptoms, treatment data and follow-up information were prospectively collected and stored in a computerized database. Analysis of variance (ANOVA) was used to relate the effect of the initial pain level, tumour volume, histology, spinal topography and dose on radiosurgery-mediated pain relief. The visual analogue scale (VAS) was used to quantify the pain level.

Results: The first consecutive 32 patients with spinal tumour associated pain treated by CyberknifeTM radiosurgery were included in this study. The median follow-up time was 4 (0,5 – 13) months. The initial median pain level was VAS=7 (range: 3 – 10). It was reduced to VAS=2 (range: 0 – 9) (p<0.0001) after radiosurgery. ANOVA revealed the initial pain score to be the most important significant variable (p<0.009) related to pain relief. The tumour volume was of lesser importance (but still significant; p<0.05). The other variables did not reach statistical significance.

Conclusions: CyberknifeTM radiosurgery is feasible and rapidly effective for control of tumour-associated spinal pain syndromes, particularly in smaller tumours.