Artikel
Spinal radiosurgery for tumour associated spinal pain
Spinale Radiochirurgie gegen spinalen Tumorschmerz
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Veröffentlicht: | 11. April 2007 |
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Gliederung
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Objective: To examine feasibility and short-term efficacy of frame less fiducial free robotic radiosurgery to control tumour associated spinal pain syndromes.
Methods: The CyberknifeTM technology including the X-sightTM software for skeletal structure tracking was used to treat tumours in the vertebral column and spinal cord. Clinical symptoms, treatment data and follow-up information were prospectively collected and stored in a computerized database. Analysis of variance (ANOVA) was used to relate the effect of the initial pain level, tumour volume, histology, spinal topography and dose on radiosurgery-mediated pain relief. The visual analogue scale (VAS) was used to quantify the pain level.
Results: The first consecutive 32 patients with spinal tumour associated pain treated by CyberknifeTM radiosurgery were included in this study. The median follow-up time was 4 (0,5 – 13) months. The initial median pain level was VAS=7 (range: 3 – 10). It was reduced to VAS=2 (range: 0 – 9) (p<0.0001) after radiosurgery. ANOVA revealed the initial pain score to be the most important significant variable (p<0.009) related to pain relief. The tumour volume was of lesser importance (but still significant; p<0.05). The other variables did not reach statistical significance.
Conclusions: CyberknifeTM radiosurgery is feasible and rapidly effective for control of tumour-associated spinal pain syndromes, particularly in smaller tumours.