gms | German Medical Science

56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
3èmes journées françaises de Neurochirurgie (SFNC)

Deutsche Gesellschaft für Neurochirurgie e. V.
Société Française de Neurochirurgie

07. bis 11.05.2005, Strasbourg

Local tissue hypoxia contributes to the vasculogenesis of dural arteriovenous fistulas

Lokale Gewebehypoxie trägt zur Vaskulogenese duraler arteriovenöser Fisteln bei

Meeting Abstract

  • corresponding author D. Miller - Klinik für Neurochirurgie, Philipps-Universität Marburg
  • W. Tirakotai - Klinik für Neurochirurgie, Philipps-Universität Marburg
  • O. Sürücü - Klinik für Neurochirurgie, Philipps-Universität Marburg
  • H. Bertalanffy - Klinik für Neurochirurgie, Philipps-Universität Marburg
  • U. Sure - Klinik für Neurochirurgie, Philipps-Universität Marburg

Deutsche Gesellschaft für Neurochirurgie. Société Française de Neurochirurgie. 56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC). Strasbourg, 07.-11.05.2005. Düsseldorf, Köln: German Medical Science; 2005. DocP066

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2005/05dgnc0334.shtml

Published: May 4, 2005

© 2005 Miller et al.
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Outline

Text

Objective

Dural arteriovenous fistulas (dAVFs) appear to be acquired lesions. The exact pathogenesis of dAVFs remains unclear, although sinus thrombosis and venous hypertension might be important factors for their formation. Earlier reports have shown that angiogenic growths factors may contribute to the development of dAVFs. Here we try to explore possible mechanisms of their pathogenesis by immunohistochemical investigation of various angiogenesis-related proteins.

Methods

We examined the expression of proteins related to proliferation (PCNA, MIB-1) and angiogenesis (bFGF, TGFα, VEGF and its receptors Flk-1 and Flt-1) as well as the hypoxia-inducible factor in surgical specimens in order to further investigate the role of hypoxia-induced angiogenesis for the pathogenesis of dAVFs.

Results

There was no positive immunostaining for MIB-1, but 3 out of 8 specimens showed a positive staining for PCNA. VEGF, Flk-1 and Flt-1 stained positively in 7, 2, and 5 of 7 specimens, respectively. Hif-1a stained positively in all available specimens.

Conclusions

DAVFs might be acquired dynamic vascular malformations with low proliferative activity. Local tissue hypoxia appears to be an important step of vasculogenesis during the formation of dAVFs.