gms | German Medical Science

56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
3èmes journées françaises de Neurochirurgie (SFNC)

Deutsche Gesellschaft für Neurochirurgie e. V.
Société Française de Neurochirurgie

07. bis 11.05.2005, Strasbourg

Neurosurgical clipping as a predictive factor of cognitive dysfunctions?

Neurochirurgische Clippung als prädiktiver Faktor kognitiver Funktionsstörungen?

Meeting Abstract

  • corresponding author J. Regelsberger - Neurochirurgische Klinik, Universitätsklinikum Hamburg-Eppendorf
  • S. Dombek - Neurochirurgische Klinik, Universitätsklinikum Hamburg-Eppendorf
  • T. Martens - Neurochirurgische Klinik, Universitätsklinikum Hamburg-Eppendorf
  • M . Westphal - Neurochirurgische Klinik, Universitätsklinikum Hamburg-Eppendorf

Deutsche Gesellschaft für Neurochirurgie. Société Française de Neurochirurgie. 56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC). Strasbourg, 07.-11.05.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc10.05.-13.04

The electronic version of this article is the complete one and can be found online at:

Published: May 4, 2005

© 2005 Regelsberger et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




Whether clipping or coiling is the best treatment option in cerebral aneurysms, one may assume in this ongoing debate that neurosurgical manipulation has an potential influence on cognitive dysfunctions due to the manipulation of the brain. A comparative study of perimesencephalic and aneurysmal SAH-patients as well as patients undergoing elective aneurysm surgery was carried out to differentiate the potential impact of SAH and surgical manipulation on long-term neuropsychological outcome.


Good neurological recovery at discharge was the inclusion criteria for standardized psychological testing concerning attention, memory, executive functions, intelligence and mood. Mean time from hospital discharge to reinvestigation was 23.43;20.50;30.43 months. There were 14 patients with a mean age of 53.9 years with a perimesencephalic SAH (Group C), Hunt&Hess (H&H) grade I-III, 13 SAH-patients (Group A), H&H grade I-III with a mean age of 52.6 years and 15 patients (mean age 53.5 years) who were surgically clipped on incidental anterior circulation aneurysms (Group B).


In the psychological tests no significant differences could have been found between perimesencephalic, aneurysmal SAH and patients with an incidental diagnosed and treated aneurysm (p>0.075). Compared with age correlated normal controls all three groups showed no significant impairment in their cognitive functions (p>0.075).


SAH-patients, independent of its origin, without focal-neurological deficits on discharge are expected to show unsuspicious neuropsychological test results on long-term follow-up. In spite these results do not differ from patients undergoing elective aneurysm surgery, we conclude that neurosurgical manipulation does not worsen the psychological long-term outcome overall in patients with cerebral aneurysms.