gms | German Medical Science

21. Jahrestagung der Retinologischen Gesellschaft gemeinsam mit dem
8. Symposium der International Society of Ocular Trauma

Deutsche Gesellschaft für Retinologie
International Society of Ocular Trauma

19.06. - 22.06.2008, Würzburg

Globe Explosion caused by intravitreal injection of triamcinolone acetonide – a case report

Meeting Abstract

Suche in Medline nach

  • Arne Viestenz - Magdeburg/Germany
  • M. Küchle - Erlangen/Germany
  • W. Behrens-Baumann - Magdeburg/Germany

Retinologische Gesellschaft. International Society of Ocular Trauma. 21. Jahrestagung der Retinologischen Gesellschaft gemeinsam mit dem 8. Symposium der International Society of Ocular Trauma. Würzburg, 19.-22.06.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. DocISOTRG2008V046

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Veröffentlicht: 18. Juni 2008

© 2008 Viestenz et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen ( Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.



Background: Intravitreal injections become more and more popular for the treatment of retinal disorders. Complications e.g. a raised intraocular pressure have been reported. The globe explosion during intravitreal injection is extremely rare.

Methods/Patient: An 83-year old female underwent injection of 0.4 ml of triamcinolone acetonide (TA) by her local ophthalmologist for age related maculopathy with lipid exudation in the left eye. During injection, globe explosion occurred with nasal limbal rupture and extrusion of intraocular contents.

Results: Emergency primary wound repair was performed at the Erlangen Eye Surgery Center. During surgery, a 9 mm limbal rupture with prolapse of half of the iris and subconjunctival extrusion of the complete natural lens was discovered. After lens removal, anterior vitrectomy and iris repositioning, the wound was closed and the eye left aphakic. Further postoperative course was unremarkable and the patient retained her preoperative visual acuity of counting fingers due to her maculopathy.

Conclusions: In this case, several factors may have contributed to the dramatic events: relative nanophthalmus (preoperative refraction + 5.0 Dpt.), scleral weakness secondary to chemotherapy for leukemia, old age, and a relatively large volume of injected TA (0.4 ml). Intravitreal injection of drugs may cause serious complications. Paracentesis or limited pars plana vitrectomy should be considered prior to intravitreal injection in high-risk cases to prevent such disastrous complication.