gms | German Medical Science

78. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

16.05. - 20.05.2007, München

Modulation of Substance P in nasal secretions by short-term immunotherapy with molecular standardized grass and rye allergens

Meeting Abstract

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  • corresponding author Oliver Pfaar - Rhinology-Center, Wiesbaden, Germany
  • author Boris Stuck - Department of Otorhinolaryngology - Head and Neck Surgery, Mannheim, Germany
  • author Karl Hoermann - Department of Otorhinolaryngology - Head and Neck Surgery, Mannheim, Germany
  • author Ludger Klimek - Rhinology-Center, Wiesbaden, Germany

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. 78th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. Munich, 16.-20.05.2007. Düsseldorf, Köln: German Medical Science; 2007. Doc07hno001

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hno2007/07hno001.shtml

Veröffentlicht: 8. August 2007

© 2007 Pfaar et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Introduction: Pathophysiologic mechanisms underlying the inflammatory processes of allergic rhinitis have been focussed in many investigations. However, evidence was found that mast cells and their specific mediators, e.g. Tryptase and Histamine, play a central role in the inflammatory cascade. Recently, neuronal mechanisms and their specific neuropeptides like Substance P (SP) revealed to co-regulate the process and could also be evaluated in the nasal secretion.

Many studies have investigated the modulation of the cellular inflammatory pathways under the specific immunotherapy (SIT). As a consequence of the knowledge of neuronal mechanisms in the nasal-inflammatory cascade it might be hypothesized that the synthesis of neuropeptides like SP should also be modulated by SIT.

Objective: The effect of short-term immunotherapy with 7 pre-seasonal injections of molecular standardized allergens from grass and rye pollen on SP in nasal secretions has been compared with symptomatic drug treatment in an open, randomized study with 48 patients over a 6-months period.

Methods: SP-levels in nasal secretions were quantified before season, in season, and after season. Furthermore, SP levels after nasal challenge test before season and after season were measured.

Results: Substance-P levels increased significantly during season in both groups. The seasonal levels for Substance P in the immunotherapy group were significantly lower than in the drug-treated group.

The post-seasonal levels decline in both groups but remain significantly higher than in pre-seasonal measurements.

After nasal challenge with grass-pollen a significant higher post-seasonal level of SP was found compared to pre-seasonal measurements in both groups. However, the SP-levels of the IT-group revealed significant lower levels compared to the control group.

Conclusion: Pre-seasonal short-term immunotherapy is able to reduce neuropeptides like SP in the nasal secretions more effectively than drug treatment in patients with allergic rhinitis.

Figure 1 [Fig. 1]

Figure 2 [Fig. 2]


References

1.
Hanf G, Schierhorn K, Brunnee T, Noga O, Verges D, Kunkel G. Substance P induced histamine release from nasal mucosa of subjects with and without allergic rhinitis. Inflamm Res. 2000;49(10):520-3.