Artikel
Five-Year Change and Incidence of Morphological Alterations of the Thyroid Gland
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Veröffentlicht: | 20. September 2011 |
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Objectives: The aim of the present study was to analyze the 5-year change and incidence of morphological alterations of the thyroid gland in a previously iodine deficient area.
Methods: Data are based on 2941 participants (1423 women; aged 20 – 79 years) of the population-based Study of Health in Pomerania (SHIP) with complete follow-up examination. Thyroid structure and size were measured by ultrasound.
Results: Between baseline and follow-up, the median iodine-creatinine ratio decreased slightly from 134.2 µg/g to 130.4 µg/g. The mean change in thyroid volume over 5 years was 0.73 ml (CI -1.68 - 3.41 ml). The incidence rate of goiter was 34.0 [CI 30.7 – 37.7] per 1000 person years (py), and the incident rate of nodules 16.6 [CI 14.5 – 19.1] per 1000 py).
Conclusions: After iodine fortification became effective in a previously iodine-deficient region, there is only a modest mean thyroid growth and a negative net balance between occurring and reverting goiter and thyroid nodules. These data suggest that the current iodine status on a lower recommended level is sufficient to prevent iodine deficiency related disorders in an adult population.