gms | German Medical Science

MAINZ//2011: 56. GMDS-Jahrestagung und 6. DGEpi-Jahrestagung

Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V.
Deutsche Gesellschaft für Epidemiologie e. V.

26. - 29.09.2011 in Mainz

Five-Year Change and Incidence of Morphological Alterations of the Thyroid Gland

Meeting Abstract

  • Henry Völzke - Ernst-Moritz-Arndt-Universität, Greifswald
  • Till Ittermann - Ernst-Moritz-Arndt-Universität, Greifswald
  • Martin Albers - Ernst-Moritz-Arndt-Universität, Greifswald
  • Nele Friedrich - Ernst-Moritz-Arndt-Universität, Greifswald
  • Matthias Nauck - Ernst-Moritz-Arndt-Universität, Greifswald
  • Harald Below - Ernst-Moritz-Arndt-Universität, Greifswald
  • Axel Kramer - Ernst-Moritz-Arndt-Universität, Greifswald
  • Henri Wallaschofski - Ernst-Moritz-Arndt-Universität, Greifswald

Mainz//2011. 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi). Mainz, 26.-29.09.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. Doc11gmds179

doi: 10.3205/11gmds179, urn:nbn:de:0183-11gmds1798

Published: September 20, 2011

© 2011 Völzke et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objectives: The aim of the present study was to analyze the 5-year change and incidence of morphological alterations of the thyroid gland in a previously iodine deficient area.

Methods: Data are based on 2941 participants (1423 women; aged 20 – 79 years) of the population-based Study of Health in Pomerania (SHIP) with complete follow-up examination. Thyroid structure and size were measured by ultrasound.

Results: Between baseline and follow-up, the median iodine-creatinine ratio decreased slightly from 134.2 µg/g to 130.4 µg/g. The mean change in thyroid volume over 5 years was 0.73 ml (CI -1.68 - 3.41 ml). The incidence rate of goiter was 34.0 [CI 30.7 – 37.7] per 1000 person years (py), and the incident rate of nodules 16.6 [CI 14.5 – 19.1] per 1000 py).

Conclusions: After iodine fortification became effective in a previously iodine-deficient region, there is only a modest mean thyroid growth and a negative net balance between occurring and reverting goiter and thyroid nodules. These data suggest that the current iodine status on a lower recommended level is sufficient to prevent iodine deficiency related disorders in an adult population.