gms | German Medical Science

104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft e. V. (DOG)

21. - 24.09.2006, Berlin

Increase of kynurenic acid (KYNA) content in the vitreous of patients with retinal detachment

Meeting Abstract

  • M. Kiczynska - Department of Ophthalmology, Medical University of Lublin
  • R. Rejdak - Department of Ophthalmology, Medical University of Lublin
  • A. Mankowska - Department of Ophthalmology, Medical University of Lublin
  • A. Oleszczuk - Department of Ophthalmology, Medical University of Lublin
  • T. Kocki - Department of Ophthalmology, Medical University of Lublin
  • T. Zarnowski - Department of Ophthalmology, Medical University of Lublin
  • W. Turski - Department of Ophthalmology, Medical University of Lublin
  • Z. Zagórski - Department of Ophthalmology, Medical University of Lublin

Deutsche Ophthalmologische Gesellschaft e.V.. 104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft (DOG). Berlin, 21.-24.09.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06dogP101

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dog2006/06dog623.shtml

Veröffentlicht: 18. September 2006

© 2006 Kiczynska et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

Synthesis of KYNA in the retina end its presence in the vitreous is well described. Moreover, alterations of KYNA synthesis in the retina in animal models of retinal degeneration have been reported. This study is the first to investigate changes of vitreous KYNA levels in patients with retinal detachment.

Methods

Vitreous fluid samples were obtained at the time of vitreoretinal surgery from 14 patients with retinal detachment. Vitreous samples obtained during surgery from 7 patients with macular holes were used as control. Total KYNA concentrations were measured with HPLC according to the method of Turski and colleagues.

Results

KYNA concentration in the vitreous of patients with retinal detachment reached the level of 2.5±0.34 pmol/ml and was significantly higher as compared to the control group (1.3±0.27 pmol/ml).

Conclusions

KYNA concentrations are increased in the vitreous of patients with retinal detachment. Enhanced endogenous KYNA synthesis might be involved in the pathomechanisms of hypoxic/ischemic insult of the outer retina.