gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Differences in macular pigment density in both eyes

Meeting Abstract

  • corresponding author A. Mößner - Klinik und Poliklinik für Augenheilkunde, Universität Leipzig, Leipzig
  • C. Jahn - Klinik und Poliklinik für Augenheilkunde, Universität Leipzig, Leipzig
  • W. Einbock - Klinik und Poliklinik für Augenheilkunde, Universität Leipzig, Leipzig
  • S. Trautmann - Klinik und Poliklinik für Augenheilkunde, Universität Leipzig, Leipzig
  • C. K. Brinkmann - Klinik und Poliklinik für Augenheilkunde, Universität Leipzig, Leipzig
  • U. E. K. Schnurrbusch - Klinik und Poliklinik für Augenheilkunde, Universität Leipzig, Leipzig
  • S. Wolf - Klinik und Poliklinik für Augenheilkunde, Universität Leipzig, Leipzig

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogDO.01.03

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dog2004/04dog003.shtml

Veröffentlicht: 22. September 2004

© 2004 Mößner et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

In this study we measured macular pigment density (MPD) of both eyes in healthy subjects and in patients with funduscopic signs of early stages of age-related maculopathy (ARM). We correlated the measured MPD of right and left eye.

Methods

MPD measurement was performed by using a modified confocal scanning laser ophthalmoscope (HRA, Heidelberg Engineering, Germany). For quantification we took autofluorescence images at two different wave lengths (488 nm and 514 nm) and MPD was evaluated within two degrees around the center of the fovea. We included 41 healthy subjects (21 women, 20 men; mean age 45,5±17,5 years) and 60 patients with early stages of ARM (42 women, 18 men; mean age 68,9±7,9 years) into the study and measured MPD in density units (DU) in both eyes.

Results

Mean MPD of healthy subjects was 0,210±0,058 DU in right eyes and 0,222±0,063 DU in left eyes. Mean difference between right and left eyes was 0,012 DU with a range of 0,329 DU. No significant difference between MPD of both eyes was found. Statistical analysis revealed a correlation of R2=0,376. Mean MPD of patients with ARM was 0,220±0,080 DU in right eyes and 0,203±0,082 DU in left eyes. Mean difference between right and left eyes was 0,018 DU with a range of 0,368 DU. There was also no significant difference in MPD between both eyes. For this group correlation was R2=0,380.

Conclusions

For healthy subjects as well as for patients with early ARM stages no significant differences between MPD of both eyes were found. However some patients showed obvious differences between both eyes. Both groups showed a slightly positive correlation between right and left eye. Further studies are necessary to elucidate our results and to investigate monocular low MPD values as a possible risk factor for ARM progression.

supported by DFG Wo 478/11