gms | German Medical Science

62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

07. - 11. Mai 2011, Hamburg

Lesions of the entopeduncular nucleus in rats worsen the disruptive effects of the NMDA receptor antagonist MK 801 on sensorimotor gating

Meeting Abstract

Suche in Medline nach

  • G. Lütjens - Klinik für Neurochirurgie, Medizinische Hochschule Hannover; Zentrum für Systemische Neurowissenschaften
  • J.K. Krauss - Klinik für Neurochirurgie, Medizinische Hochschule Hannover; Zentrum für Systemische Neurowissenschaften
  • K. Schwabe - Klinik für Neurochirurgie, Medizinische Hochschule Hannover; Zentrum für Systemische Neurowissenschaften

Deutsche Gesellschaft für Neurochirurgie. Polnische Gesellschaft für Neurochirurgen. 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH). Hamburg, 07.-11.05.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. DocP 093

DOI: 10.3205/11dgnc314, URN: urn:nbn:de:0183-11dgnc3148

Veröffentlicht: 28. April 2011

© 2011 Lütjens et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective: Sensorimotor gating is disturbed in certain neuropsychiatric disorders with known or proposed abnormalities of basal ganglia function such as schizophrenia, obsessive compulsive disorder and Tourette's syndrome. Prepulse inhibition (PPI) of the acoustic startle reaction is an operational measure of sensorimotor gating, and PPI deficits induced by NMDA receptor antagonists serve as an animal model for neuropsychiatric symptoms. Little is known, however, about the role of the entopeduncular nucleus (EPN, i.e., the rat equivalent to the human globus pallidus internus) in pharmacologically induced PPI deficits although the EPN is an important output structure of the basal ganglia and its human equivalent used in functional neurosurgery.

Methods: In male Sprague Dawley rats bilateral EPN lesions were induced by stereotaxic injection of ibotenate (4 µg in 0.4 µl; n=11) or sham-lesions by injection of a vehicle (n=7). Rats were then tested for PPI of ASR in a startle response system and for locomotor activity in an open field after subcutaneous injection of the NMDA receptor antagonist MK801 (0.0 mg/kg and 0.15 mg/kg).

Results: EPN lesions did not affect baseline PPI but worsened the PPI-disruptive effect of MK801 in lesioned compared to sham-lesioned rats (two-way ANOVA with post-hoc Tukey's test, p < 0.05). Locomotor activity was significantly higher after drug injection in both sham-lesioned and lesioned rats (p < 0.05) without a difference between the two groups.

Conclusions: These data suggest that the EPN is an important brain region within the neuronal circuit responsible for NMDA receptor antagonist-induced deficient sensorimotor gating.