gms | German Medical Science

58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

26. bis 29.04.2007, Leipzig

Experimental investigation of doxorubicin and irinotecan loaded microspheres for intratumoral treatment of glioma

Experimentelle Untersuchung von Doxorubicin- oder Irinotecangeladenen Mikrosphären für die intratumorale Behandlung von Gliomen

Meeting Abstract

  • corresponding author I. Freund - International Neuroscience Institute GmbH, Hannover
  • S. Baltes - International Neuroscience Institute GmbH, Hannover
  • P. Klinge - International Neuroscience Institute GmbH, Hannover
  • A. Samii - International Neuroscience Institute GmbH, Hannover
  • C. Wallrapp - CellMed AG, Alzenau
  • T. Brinker - International Neuroscience Institute GmbH, Hannover

Deutsche Gesellschaft für Neurochirurgie. 58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC). Leipzig, 26.-29.04.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. DocDO.02.07

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2007/07dgnc017.shtml

Veröffentlicht: 11. April 2007

© 2007 Freund et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective: Doxorubicin and irinotecan loaded microspheres are specifically designed to and clinically used for trans-arterial chemo-embolisation of tumors. In a rat model it is investigated whether these microspheres may be used for intratumoral glioma therapy.

Methods: Doxorubicin or irinotecan loaded micropsheres (DC BeadsTM, Biocompatibles, Farnham, UK) were stereotactically implanted seven days after stereotactic implantation of BT4ca malignant glioma cells into the brain of BDIX rats (syngenic tumor model). Survival and histomorphological findings were compared between an untreated control group, a group receiving unloaded microspheres and a group receiving doxorubicin or irinotecan loaded micropheres. Size of groups n=10.

Results: After implantation of Doxorubicin Kaplan Meier Analysis showed a doubling of survival time (p<0.05) while the prolongation of survival time with Irinotecan was not significant. Histomorphological investigation depicted marked regressive effects within the tumors with both doxorubicin and irinotecan. In doxorubicin treated animals in addition a hemorrhagic imbibition of the tumor was found.

Conclusions: Intratumoral implantation of Doxorubicin loaded DC BeadsTM decreased the mortality of BT4Ca tumor-bearing rats. This effect could be related histologically to necrosis of the tumors. The experimental findings have clinical relevance, because such microspheres could be readily implanted by stereotaxy either into the tumor or into the tumor resection borders.