gms | German Medical Science

57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

11. bis 14.05.2006, Essen

The relationship between histopathological findings and 5-aminolevulinic acid induced fluorescence in glioma surgery

Meeting Abstract

  • corresponding author Y. Kajimoto - Department of Neurosurgery, Osaka Medical College, Osaka, Japan
  • T. Masubuchi - Department of Neurosurgery, Osaka Medical College, Osaka, Japan
  • H. Tanaka - Department of Neurosurgery, Osaka Medical College, Osaka, Japan
  • M. Miyashita - Department of Neurosurgery, Osaka Medical College, Osaka, Japan
  • J. Aoki - Department of Neurosurgery, Osaka Medical College, Osaka, Japan
  • S.I. Miyatake - Department of Neurosurgery, Osaka Medical College, Osaka, Japan
  • T. Kuroiwa - Department of Neurosurgery, Osaka Medical College, Osaka, Japan

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. Essen, 11.-14.05.2006. Düsseldorf, Köln: German Medical Science; 2006. DocFR.07.03

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2006/06dgnc043.shtml

Veröffentlicht: 8. Mai 2006

© 2006 Kajimoto et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective: It is relative easy to remove the main mass of the malignant glioma, which shows strong fluorescence induced by 5-aminolevulinic acid (5-ALA). However, in order to remove the tumor maximally with preservation of neurological function, it is important to understand the implication of the fluorescence at the marginal zone of the tumor.

Methods: In this study, we characterized histopathological findings at the strong, vague fluorescent area in marginal zone (marginal vague) in four cases of glioblastoma.

Results: At the strong fluorescent area, the most of the cells were tumor cells and neuronal structures were destroyed. However, at the marginal vague fluorescent area, neuronal structures were almost preserved and tumor cell densities were less than 1/10 than that of the strong fluorescent area.

Conclusions: The vague fluorescence area, which is adjacent to the eloquent area, should not be removed so that neurologic function is preserved. On the other hand, the vague fluorescence area of the non-eloquent area should be extensively removed for tumor cell reduction.