gms | German Medical Science

55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

25. bis 28.04.2004, Köln

Biomarkers: A novel tool for the monitoring of severe brain injury

Meeting Abstract

  • corresponding author Andrs Buki - Department of Neurosurgery, Medical Faculty of Pcs University, Pcs /H
  • O. Farkas - Department of Neurosurgery, Clinical Microbiology and Immunology, Medical Faculty of Pcs University, Pcs /H
  • J. Pl - Department of Neurosurgery, Medical Faculty of Pcs University, Pcs /H
  • T. Doczi - Department of Neurosurgery, Medical Faculty of Pcs University, Pcs /H
  • J. T. Povlishock - Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond /USA
  • J. Pineda - Department of Neuroscience, Evelyn F and William L McKnight Brain Institute of the University of Florida, Center for Traumatic Brain Injury Studies, Gainesville /USA
  • K. W. W. Wang - Department of Neuroscience, Evelyn F and William L McKnight Brain Institute of the University of Florida, Center for Traumatic Brain Injury Studies, Gainesville /USA
  • R. Hayes - Department of Neuroscience, Evelyn F and William L McKnight Brain Institute of the University of Florida, Center for Traumatic Brain Injury Studies, Gainesville /USA

Deutsche Gesellschaft fr Neurochirurgie. Ungarische Gesellschaft fr Neurochirurgie. 55. Jahrestagung der Deutschen Gesellschaft fr Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft fr Neurochirurgie. Kln, 25.-28.04.2004. Dsseldorf, Kln: German Medical Science; 2004. DocJM II.03

Die elektronische Version dieses Artikels ist vollstndig und ist verfgbar unter: http://www.egms.de/de/meetings/dgnc2004/04dgnc0003.shtml

Veröffentlicht: 23. April 2004

© 2004 Buki et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Calcium-induced proteolytic processes are considered key players in traumatic brain injury (TBI). This study was initiated to detect spectrin-breakdown product (SBDP) accumulation in the ventricular cerebrospinal fluid (CSF) of 12 severe TBI-patients with raised intracranial pressure (ICP). Nine patients with acute hydrocephalus and five, undergone diagnostic lumbar puncture constituted the control groups. SBDP were detected in Western blots. The results of our study demonstrated a reliable temporal pattern for non-erythroid alpha-II-spectrin and SBDP accumulation in TBI reaching significantly higher level in comparison with other pathological conditions associated with increased ICP. A tendency for negative correlation between the accumulation of spectrin and some SBDP and injury severity could be observed. SBDP-levels may provide useful information on the severity of brain injury of various origin and particularly could be important in the monitoring of proteolytic processes in TBI.

These results will be contrasted with findigs of rodent experiments analyzing the occurrence and concentration of non-erythroid alpha-II-spectrin and SBDP in various experimental models of TBI while also discussing potential utilization of other surrogate biomarkers.