gms | German Medical Science

55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

25. bis 28.04.2004, Köln

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Biomarkers: A novel tool for the monitoring of severe brain injury

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  • corresponding author András Buki - Department of Neurosurgery, Medical Faculty of Pécs University, Pécs /H
  • O. Farkas - Department of Neurosurgery, Clinical Microbiology and Immunology, Medical Faculty of Pécs University, Pécs /H
  • J. Pál - Department of Neurosurgery, Medical Faculty of Pécs University, Pécs /H
  • T. Doczi - Department of Neurosurgery, Medical Faculty of Pécs University, Pécs /H
  • J. T. Povlishock - Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond /USA
  • J. Pineda - Department of Neuroscience, Evelyn F and William L McKnight Brain Institute of the University of Florida, Center for Traumatic Brain Injury Studies, Gainesville /USA
  • K. W. W. Wang - Department of Neuroscience, Evelyn F and William L McKnight Brain Institute of the University of Florida, Center for Traumatic Brain Injury Studies, Gainesville /USA
  • R. Hayes - Department of Neuroscience, Evelyn F and William L McKnight Brain Institute of the University of Florida, Center for Traumatic Brain Injury Studies, Gainesville /USA

Deutsche Gesellschaft für Neurochirurgie. Ungarische Gesellschaft für Neurochirurgie. 55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie. Köln, 25.-28.04.2004. Düsseldorf, Köln: German Medical Science; 2004. DocJM II.03

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2004/04dgnc0003.shtml

Published: April 23, 2004

© 2004 Buki et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Calcium-induced proteolytic processes are considered key players in traumatic brain injury (TBI). This study was initiated to detect spectrin-breakdown product (SBDP) accumulation in the ventricular cerebrospinal fluid (CSF) of 12 severe TBI-patients with raised intracranial pressure (ICP). Nine patients with acute hydrocephalus and five, undergone diagnostic lumbar puncture constituted the control groups. SBDP were detected in Western blots. The results of our study demonstrated a reliable temporal pattern for non-erythroid alpha-II-spectrin and SBDP accumulation in TBI reaching significantly higher level in comparison with other pathological conditions associated with increased ICP. A tendency for negative correlation between the accumulation of spectrin and some SBDP and injury severity could be observed. SBDP-levels may provide useful information on the severity of brain injury of various origin and particularly could be important in the monitoring of proteolytic processes in TBI.

These results will be contrasted with findigs of rodent experiments analyzing the occurrence and concentration of non-erythroid alpha-II-spectrin and SBDP in various experimental models of TBI while also discussing potential utilization of other surrogate biomarkers.