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21st Annual Meeting of the German Retina Society and 8th Symposium of the International Society of Ocular Trauma (ISOT)

German Retina Society
International Society of Ocular Trauma

19.06. - 22.06.2008, Würzburg

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Limbal stem cells transplantation in chemical and thermal burns

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  • Edward Wylegala - Katowice/Poland
  • D. Dobrowolski - Katowice/Poland
  • D. Tarnawska - Katowice/Poland

Retinologische Gesellschaft. International Society of Ocular Trauma. 21. Jahrestagung der Retinologischen Gesellschaft gemeinsam mit dem 8. Symposium der International Society of Ocular Trauma. Würzburg, 19.-22.06.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. DocISOTRG2008V058

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/rg2008/08rg060.shtml

Published: June 18, 2008

© 2008 Wylegala et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Background: To analyse the graft survival rate and stability of the corneal surface in patients, who underwent limbal stem cells transplantation. Three surgical techniques were applied: CLAU, lrCLAL, and KLAL transplantations.

Methods: Nonrandomized consecutive comparative case series study. For the analysis we qualified: 52 patients (52 eyes), 11 women and 41 men, aged from 11 to 78 years. Mean follow–up was 28,4, range from 8 to 72 months. Three groups: CLAU, lrCLAL and KLAL contained 16, 7 and 29 eyes respectively. Graft survival rate and clinical success of stem cells transplantation in impression cytology was evaluated. Kaplan Meier survival curve was used.

Results: Comparison of the graft survival and regularity of corneal surface between allo- and autografts showed statistically significant difference. Three years graft survival rate was 87,5% in autologous transplantation group and 47,2% in allogenic transplantation group. After six years it was 81,2% and 33,3% respectively. Restoration of corneal surface was confirmed by impression cytology.

Conclusions: Autotransplantation of the limbus in ocular surface burns shows significantly better long-term outcomes.