Article
Number of home measurements needed to identify responders in the Olmetel study
Benötigte Anzahl von Heimblutdruckmessungen zur Identifikation der Responder in der Olmetel Studie
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Authors
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S. Ewald
- Sankyo Pharma GmbH, Clinical Development Nünchen (München, D)
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J. vor dem Esche
- Telemed Project GmbH, Bergisch Gladbach (Bergisch Gladbach, D)
| Published: | August 8, 2006 |
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Outline
Text
Objective: We have recently shown that blood pressure self-measurement (BPSM) supervised by telemonitoring gave a detailed impression of BP-development under Olmesartan treatment in a real life clinical setting. The question was how many regular BP readings per week are necessary to detect a BP reduction of at least 5 mmHg.
Methods: Patients (n= 53) suffering from essential hypertension were treated with Olmesartan 10-40 mg/day. BPSM was conducted throughout a 9-week period using a TensioPhone TP2 device; BP values were stored and automatically downloaded to a remote service centre via standard telephone lines. The patients were instructed to measure their BP twice per day. To estimate the predictive power of the number of measurements a sample size (1, 2, 3…7) was randomly drawn from the measurements of each patient at week 9. This procedure was repeated 1000 times. Rates of a correct prediction of response to the antihypertensive treatment (sensitivity, specifity) were estimated. A sensitivity of greater than 90% and a specifity greater than 90% to detect a BP reduction > 5 mmHg were defined to give reliable data.
Results: Rates of correct prediction of response for defined number of home readings are given in the graph (Figure 1 [Fig. 1]).
Conclusion: A number of at least 5 BP home readings per week was identified to give a correct prediction of response to Olmesartan treatment.
