gms | German Medical Science

29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Hochdruckliga e. V. DHL ® - Deutsche Hypertonie Gesellschaft Deutsches Kompetenzzentrum Bluthochdruck

23. bis 25.11.2005, Berlin

Number of home measurements needed to identify responders in the Olmetel study

Benötigte Anzahl von Heimblutdruckmessungen zur Identifikation der Responder in der Olmetel Studie

Meeting Abstract

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  • S. Ewald - Sankyo Pharma GmbH, Clinical Development Nünchen (München, D)
  • J. vor dem Esche - Telemed Project GmbH, Bergisch Gladbach (Bergisch Gladbach, D)

Hypertonie 2005. 29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Berlin, 23.-25.11.2005. Düsseldorf, Köln: German Medical Science; 2006. Doc05hochP26

The electronic version of this article is the complete one and can be found online at:

Published: August 8, 2006

© 2006 Ewald et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: We have recently shown that blood pressure self-measurement (BPSM) supervised by telemonitoring gave a detailed impression of BP-development under Olmesartan treatment in a real life clinical setting. The question was how many regular BP readings per week are necessary to detect a BP reduction of at least 5 mmHg.

Methods: Patients (n= 53) suffering from essential hypertension were treated with Olmesartan 10-40 mg/day. BPSM was conducted throughout a 9-week period using a TensioPhone TP2 device; BP values were stored and automatically downloaded to a remote service centre via standard telephone lines. The patients were instructed to measure their BP twice per day. To estimate the predictive power of the number of measurements a sample size (1, 2, 3…7) was randomly drawn from the measurements of each patient at week 9. This procedure was repeated 1000 times. Rates of a correct prediction of response to the antihypertensive treatment (sensitivity, specifity) were estimated. A sensitivity of greater than 90% and a specifity greater than 90% to detect a BP reduction > 5 mmHg were defined to give reliable data.

Results: Rates of correct prediction of response for defined number of home readings are given in the graph (Figure 1 [Fig. 1]).

Conclusion: A number of at least 5 BP home readings per week was identified to give a correct prediction of response to Olmesartan treatment.