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29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Hochdruckliga e. V. DHL ® - Deutsche Hypertonie Gesellschaft Deutsches Kompetenzzentrum Bluthochdruck

23. bis 25.11.2005, Berlin

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Impaired renal allograft function is associated with increased vascular stiffness

Verminderte Gefäßelastizität bei Patienten mit chronischer Transplantatnephropathie

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  • M. Kneifel - Charité- Universitätsmedizin Berlin-CBF (Berlin, D)
  • A. Scholze - Charité- Universitätsmedizin Berlin-CBF (Berlin, D)
  • A. Burkert - Charité- Universitätsmedizin Berlin-CBF (Berlin, D)
  • G. Offermann - Charité- Universitätsmedizin Berlin-CBF (Berlin, D)
  • L. Rothermund - Charité- Universitätsmedizin Berlin-CBF (Berlin, D)
  • W. Zidek - Charité- Universitätsmedizin Berlin-CBF (Berlin, D)

Hypertonie 2005. 29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Berlin, 23.-25.11.2005. Düsseldorf, Köln: German Medical Science; 2006. Doc05hochP7

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hoch2005/05hoch007.shtml

Published: August 8, 2006

© 2006 Kneifel et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Impaired renal allograft function is associated with increased vascular stiffness Background. Progressive impairment of renal function is frequently observed in patients with renal allografts. It is unknown whether progressive impairment of renal allograft function deteriorates vascular characteristics including vascular stiffness and endothelial function.

Methods. Vascular characteristics were non-invasively measured in 48 patients with renal allograft and impaired renal function. Mean age was 51 ± 2 years (mean ± SEM) and follow-up period was 17 ± 1 months. The stages of chronic kidney disease were based on the level of creatinine clearance. Arterial stiffness was determined by applanation tonometry and endothelial function was evaluated during flow-mediated vasodilation using digital photoplethysmography.

Results. We observed a significant association between the stage of chronic kidney disease and arterial stiffness of large arteries S1 or small arteries S2 (each p < 0.05 by non-parametric Kruskal-Wallis-test between groups). Multivariate linear regression analysis showed that only gender of patient with renal allograft (p = 0.001), creatinine clearance (p = 0.01), and age of kidney donor (p = 0.04) were independently associated with large artery stiffness S1. In addition, a significant association between the stage of chronic kidney disease and impaired endothelial function was observed (p < 0.05 by non-parametric Kruskal-Wallis-test between groups). Impaired endothelial function was significantly correlated with calcium x phosphate product (Spearman r = 0.29; p = 0.042).

Conclusion. It is concluded that increased vascular stiffness in patients with renal allograft could be observed with progressive impairment of renal allograft function.

Key words: patients with renal allograft, chronic renal disease, endothelial dysfunction, vascular stiffness