gms | German Medical Science

29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Hochdruckliga e. V. DHL ® - Deutsche Hypertonie Gesellschaft Deutsches Kompetenzzentrum Bluthochdruck

23. bis 25.11.2005, Berlin

Impaired renal allograft function is associated with increased vascular stiffness

Verminderte Gefäßelastizität bei Patienten mit chronischer Transplantatnephropathie

Meeting Abstract

  • M. Kneifel - Charité- Universitätsmedizin Berlin-CBF (Berlin, D)
  • A. Scholze - Charité- Universitätsmedizin Berlin-CBF (Berlin, D)
  • A. Burkert - Charité- Universitätsmedizin Berlin-CBF (Berlin, D)
  • G. Offermann - Charité- Universitätsmedizin Berlin-CBF (Berlin, D)
  • L. Rothermund - Charité- Universitätsmedizin Berlin-CBF (Berlin, D)
  • W. Zidek - Charité- Universitätsmedizin Berlin-CBF (Berlin, D)

Hypertonie 2005. 29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Berlin, 23.-25.11.2005. Düsseldorf, Köln: German Medical Science; 2006. Doc05hochP7

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hoch2005/05hoch007.shtml

Veröffentlicht: 8. August 2006

© 2006 Kneifel et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Impaired renal allograft function is associated with increased vascular stiffness Background. Progressive impairment of renal function is frequently observed in patients with renal allografts. It is unknown whether progressive impairment of renal allograft function deteriorates vascular characteristics including vascular stiffness and endothelial function.

Methods. Vascular characteristics were non-invasively measured in 48 patients with renal allograft and impaired renal function. Mean age was 51 ± 2 years (mean ± SEM) and follow-up period was 17 ± 1 months. The stages of chronic kidney disease were based on the level of creatinine clearance. Arterial stiffness was determined by applanation tonometry and endothelial function was evaluated during flow-mediated vasodilation using digital photoplethysmography.

Results. We observed a significant association between the stage of chronic kidney disease and arterial stiffness of large arteries S1 or small arteries S2 (each p < 0.05 by non-parametric Kruskal-Wallis-test between groups). Multivariate linear regression analysis showed that only gender of patient with renal allograft (p = 0.001), creatinine clearance (p = 0.01), and age of kidney donor (p = 0.04) were independently associated with large artery stiffness S1. In addition, a significant association between the stage of chronic kidney disease and impaired endothelial function was observed (p < 0.05 by non-parametric Kruskal-Wallis-test between groups). Impaired endothelial function was significantly correlated with calcium x phosphate product (Spearman r = 0.29; p = 0.042).

Conclusion. It is concluded that increased vascular stiffness in patients with renal allograft could be observed with progressive impairment of renal allograft function.

Key words: patients with renal allograft, chronic renal disease, endothelial dysfunction, vascular stiffness