gms | German Medical Science

27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Liga zur Bekämpfung des hohen Blutdrucks – Deutsche Hypertonie Gesellschaft e. V.

26. bis 29.11.2003, Bonn

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Blood pressure values correlate with the metabolic burden in obese patients

Die Blutdruckwerte korrelieren bei adipösen Patienten mit der metabolischen Belastung

Meeting Abstract (Hypertonie 2003)

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  • presenting/speaker J. Scholze - Charité CCM, Inst. f. Pharmakologie u. Toxikologie (Berlin, D)
  • T. Unger - Charité CCM, Inst. f. Pharmakologie u. Toxikologie (Berlin, D)

Hypertonie 2003. 27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Bonn, 26.-29.11.2003. Düsseldorf, Köln: German Medical Science; 2004. Doc03hochP44

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hoch2003/03hoch144.shtml

Published: November 11, 2004

© 2004 Scholze et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

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Obesity, defined as exceeding a body mass index of 30 kg/m² has reached endemic proportions and is a substantial risk factor for metabolic and cardiovascular diseases. Up to now it remains unclear, why many obese patients develop metabolic disorders while others do not.

To investigate the influence of blood pressure levels on metabolic parameters, we compared these data from 6360 obese patients of the sibutramine-PMS-study with a BMI of at least 27 kg/m² [1].

Patients were divided into 3 groups according blood pressure levels (A:<140/90 mmHg- normotensive, B: 140-159/90-99 mmHg-stage 1 hypertensive and C: > 160/100 mmHg-stage 2 hypertensive). The following parameters were determined: Chol, LDL, HDL, triglyceride (TG), Glucose, HbA1c, uric acid, heart rate (HR). Groups were not different with respect to body weight, gender and age.

All differences of the parameters between the groups listed in table 1 [Tab. 1], were significant p < 0,05.

In addition, there was a significant increase of HR (74,7 vs 77,0 vs. 82,1 b/min) from group A to C.

We found a strong dependence of metabolic disorders on blood pressure levels. Both seems to be influenced by the degree of activation of the sympathetic nervous system.

Outline

References

1.
J. Scholze, Dtsch. Med Wochenschr. 2002; 127: 606-610