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78th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

16.05. - 20.05.2007, Munich

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Gene-expression study of possible target genes harbouring the chromosomal region 3q26-28 in HNSCC

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  • corresponding author Jan Kastner - HNO-Klinik Prag-Motol, Prag - Motol, Tschechische Republik
  • Jürgen Brieger - Tumorbiologie Labor, HNO Klinik, Mainz
  • Wolf J. Mann - HNO Klinik, Mainz
  • Jan Betka - HNO Klinik Prag-Motol, Prag, Tschechische Republik
  • Jan Plzak - HNO Klinik Prag-Motol, Prag, Tschechische Republik
  • Tomas Zima - Institute of Clinical Biochemistry and Laboratory Diagnostics, Prag, Tschechische Republik

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 78. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.. München, 16.-20.05.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. Doc07hnod178

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hnod2007/07hnod178.shtml

Published: April 24, 2007

© 2007 Kastner et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Amplification of chromosomal region 3q26-28 is a common event in head and neck squamous cell carcinoma. We applied a real time PCR to evaluate gene expression of several candidate oncogenes harbouring 3q26-28 in tumor samples as well as in histologically normal tissue samples nearby the tumor margin. It has been detected an overexpression of particular genes (PIK3CA, SSCRO and others) in tumor surrounding samples which might play a crucial role in early stages of cancerogenesis and tumor progression.

Supported by: Tumorstiftung Kopf-Hals (Germany), Grant GAUK Nr.203435 36/06 (Czech Republic)