gms | German Medical Science

76th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

04.05. - 08.05.2005, Erfurt

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TFF-peptides in the human false vocal folds of the larynx

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  • corresponding author Hannes Kutta - Department of Oto-Rhino-Laryngology, University Hospital Hamburg Eppendorf, Germany
  • author Friedrich Paulsen - Institute of Anatomy and Cellbiology, University of Halle/Saale, Germany, Halle (Saale)

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 76. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.. Erfurt, 04.-08.05.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc05hno307

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hno2005/05hno083.shtml

Published: September 22, 2005

© 2005 Kutta et al.
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Outline

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TFF-peptides are typical secretory products of mucin-producing cells and are thought to influence the rheological properties of mucous gels. Here, the localization of these peptides in the human false vocal folds of the larynx was investigated. An analysis of TFF-peptide mRNA by RT-PCR and TFF-protein by Western blot detected TFF1 and TFF3, but not TFF2. Immunohistochemistry revealed TFF1 to be associated with the secretory product of goblet cells and mucous parts of subepithelial seromucous glands. TFF3 occurred in columnar epithelial cells of the mucosa and in serous cells and excretory duct cells of seromucous glands. These peptides may play a role in the rheological function of mucus secreted on the true vocal folds and thus, are important constituents for vocal production.