gms | German Medical Science

104th DOG Annual Meeting

21. - 24.09.2006, Berlin

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Increase of kynurenic acid (KYNA) content in the vitreous of patients with retinal detachment

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  • M. Kiczynska - Department of Ophthalmology, Medical University of Lublin
  • R. Rejdak - Department of Ophthalmology, Medical University of Lublin
  • A. Mankowska - Department of Ophthalmology, Medical University of Lublin
  • A. Oleszczuk - Department of Ophthalmology, Medical University of Lublin
  • T. Kocki - Department of Ophthalmology, Medical University of Lublin
  • T. Zarnowski - Department of Ophthalmology, Medical University of Lublin
  • W. Turski - Department of Ophthalmology, Medical University of Lublin
  • Z. Zagórski - Department of Ophthalmology, Medical University of Lublin

Deutsche Ophthalmologische Gesellschaft e.V.. 104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft (DOG). Berlin, 21.-24.09.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06dogP101

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dog2006/06dog623.shtml

Published: September 18, 2006

© 2006 Kiczynska et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective

Synthesis of KYNA in the retina end its presence in the vitreous is well described. Moreover, alterations of KYNA synthesis in the retina in animal models of retinal degeneration have been reported. This study is the first to investigate changes of vitreous KYNA levels in patients with retinal detachment.

Methods

Vitreous fluid samples were obtained at the time of vitreoretinal surgery from 14 patients with retinal detachment. Vitreous samples obtained during surgery from 7 patients with macular holes were used as control. Total KYNA concentrations were measured with HPLC according to the method of Turski and colleagues.

Results

KYNA concentration in the vitreous of patients with retinal detachment reached the level of 2.5±0.34 pmol/ml and was significantly higher as compared to the control group (1.3±0.27 pmol/ml).

Conclusions

KYNA concentrations are increased in the vitreous of patients with retinal detachment. Enhanced endogenous KYNA synthesis might be involved in the pathomechanisms of hypoxic/ischemic insult of the outer retina.