Article
The mechanism of rupture of intracranial aneurysm
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Published: | May 8, 2006 |
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Outline
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Objective: Rupture of intracranial aneurysm produces subarachnoid hemorrhage that is one of the most severe forms of stroke. To predict aneurysmal rupture, a good understanding of the mechanism of aneurysmal initiation, growth and rupture is necessary. We have studied the flow behavior by use of glass models.
Methods: We have studied the flow behavior in the aneurysm by implanting the endothelialized glass models into the canine carotid arteries. The models were exposed to blood flow and flows inside the aneurysms were monitored with CCD camera 2 hours. Then specimens were perfusion-fixed and examined by scanning electron microscopy.
Results: Flow visualization revealed that white thrombus formation developed inside aneurysms at the flow separation and stagnant point. Then thrombus grew and flew away with circulating blood from the aneurysms. This thrombus formation repeatedly occurred in the aneurysm domes.
Conclusions: The experimental studies suggested that the subsequent fibrinolysis after the thrombus formation must play an important role for aneurysm rupture rather than a blow-up mechanism.