gms | German Medical Science

57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

11. bis 14.05.2006, Essen

The mechanism of rupture of intracranial aneurysm

Meeting Abstract

  • corresponding author H. Ujiie - Department of Neurosurgery, Neurological Institute, Tokyo Women’s Medical University, Tokyo, Japan; Beam application team, Biopolymer Physics Laboratory, the Institute of Physical and Chemical Research, Wako, Japan
  • Y. Suzuki - Department of Neurosurgery, Neurological Institute, Tokyo Women’s Medical University, Tokyo, Japan; Beam application team, Biopolymer Physics Laboratory, the Institute of Physical and Chemical Research, Wako, Japan
  • N. Takahashi - Department of Neurosurgery, Neurological Institute, Tokyo Women’s Medical University, Tokyo, Japan; Beam application team, Biopolymer Physics Laboratory, the Institute of Physical and Chemical Research, Wako, Japan
  • M. Kaibara - Department of Neurosurgery, Neurological Institute, Tokyo Women’s Medical University, Tokyo, Japan; Beam application team, Biopolymer Physics Laboratory, the Institute of Physical and Chemical Research, Wako, Japan
  • T. Hori - Department of Neurosurgery, Neurological Institute, Tokyo Women’s Medical University, Tokyo, Japan; Beam application team, Biopolymer Physics Laboratory, the Institute of Physical and Chemical Research, Wako, Japan

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. Essen, 11.-14.05.2006. Düsseldorf, Köln: German Medical Science; 2006. DocP 10.154

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2006/06dgnc371.shtml

Veröffentlicht: 8. Mai 2006

© 2006 Ujiie et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective: Rupture of intracranial aneurysm produces subarachnoid hemorrhage that is one of the most severe forms of stroke. To predict aneurysmal rupture, a good understanding of the mechanism of aneurysmal initiation, growth and rupture is necessary. We have studied the flow behavior by use of glass models.

Methods: We have studied the flow behavior in the aneurysm by implanting the endothelialized glass models into the canine carotid arteries. The models were exposed to blood flow and flows inside the aneurysms were monitored with CCD camera 2 hours. Then specimens were perfusion-fixed and examined by scanning electron microscopy.

Results: Flow visualization revealed that white thrombus formation developed inside aneurysms at the flow separation and stagnant point. Then thrombus grew and flew away with circulating blood from the aneurysms. This thrombus formation repeatedly occurred in the aneurysm domes.

Conclusions: The experimental studies suggested that the subsequent fibrinolysis after the thrombus formation must play an important role for aneurysm rupture rather than a blow-up mechanism.