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57th Annual Meeting of the German Society of Neurosurgery
Joint Meeting with the Japanese Neurosurgical Society

German Society of Neurosurgery (DGNC)

11 - 14 May, Essen

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The relationship between histopathological findings and 5-aminolevulinic acid induced fluorescence in glioma surgery

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  • corresponding author Y. Kajimoto - Department of Neurosurgery, Osaka Medical College, Osaka, Japan
  • T. Masubuchi - Department of Neurosurgery, Osaka Medical College, Osaka, Japan
  • H. Tanaka - Department of Neurosurgery, Osaka Medical College, Osaka, Japan
  • M. Miyashita - Department of Neurosurgery, Osaka Medical College, Osaka, Japan
  • J. Aoki - Department of Neurosurgery, Osaka Medical College, Osaka, Japan
  • S.I. Miyatake - Department of Neurosurgery, Osaka Medical College, Osaka, Japan
  • T. Kuroiwa - Department of Neurosurgery, Osaka Medical College, Osaka, Japan

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. Essen, 11.-14.05.2006. Düsseldorf, Köln: German Medical Science; 2006. DocFR.07.03

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2006/06dgnc043.shtml

Published: May 8, 2006

© 2006 Kajimoto et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective: It is relative easy to remove the main mass of the malignant glioma, which shows strong fluorescence induced by 5-aminolevulinic acid (5-ALA). However, in order to remove the tumor maximally with preservation of neurological function, it is important to understand the implication of the fluorescence at the marginal zone of the tumor.

Methods: In this study, we characterized histopathological findings at the strong, vague fluorescent area in marginal zone (marginal vague) in four cases of glioblastoma.

Results: At the strong fluorescent area, the most of the cells were tumor cells and neuronal structures were destroyed. However, at the marginal vague fluorescent area, neuronal structures were almost preserved and tumor cell densities were less than 1/10 than that of the strong fluorescent area.

Conclusions: The vague fluorescence area, which is adjacent to the eloquent area, should not be removed so that neurologic function is preserved. On the other hand, the vague fluorescence area of the non-eloquent area should be extensively removed for tumor cell reduction.