gms | German Medical Science

56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
3èmes journées françaises de Neurochirurgie (SFNC)

Deutsche Gesellschaft für Neurochirurgie e. V.
Société Française de Neurochirurgie

07. bis 11.05.2005, Strasbourg

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First results of deep brain stimulation in patients with therapy resistant obsessive compulsive disorder

Erste Ergebnisse der Tiefenhirnstimulation bei therapieresistenten Zwangserkrankungen

Meeting Abstract

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  • corresponding author D. Lenartz - Klinik für Stereotaxie und funktionelle Neurochirurgie, Universitätsklinik Köln
  • A. Koulousakis - Klinik für Stereotaxie und funktionelle Neurochirurgie, Universitätsklinik Köln
  • H. Treuer - Klinik für Stereotaxie und funktionelle Neurochirurgie, Universitätsklinik Köln
  • M. Schormann - Klinik für Psychiatrie und Psychotherapie, Universitätsklinik Köln
  • S.-H. Lee - Klinik für Psychiatrie und Psychotherapie, Universitätsklinik Köln
  • V. Hesselmann - Klinik für Radiologie, Universitätsklinik Köln
  • V. Sturm - Klinik für Stereotaxie und funktionelle Neurochirurgie, Universitätsklinik Köln

Deutsche Gesellschaft für Neurochirurgie. Société Française de Neurochirurgie. 56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC). Strasbourg, 07.-11.05.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc11.05.-10.12

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2005/05dgnc0226.shtml

Published: May 4, 2005

© 2005 Lenartz et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective

Permanent high frequency stimulation in relevant brain regions can be a new therapeutical option in severe therapy resistant obsessive compulsive disorder. In this indication deep brain stimulation has the same advantages as in movement disorder treatment, which is reversibility at any time. The fact that deep brain stimulation can be inactivated at any time during therapy, provides many advantages for experimental research on the mechanisms of action of different targets in the brain as well as neurobiological circuits.

Methods

We have started together with our department of psychiatry a prospective randomised study to evaluate the effects of deep brain stimulation of the right nucleus accumbens in therapy resistant obsessive compulsive disorder. The study is a randomised double blind therapy study with follow-up-examinations over two years. After evaluation of all inclusion and exclusion criteria, the patients undergo stereotactic implantation of DBS electrodes into the shell of the right nucleus accumbens with connection to a subcutaneously implanted pacemaker.

Results

The effects of deep brain stimulation on symptom predominance and quality of life are measured. Therefore several clinical and psychometric tests at different time points are applied. Additional intraoperative f-MRI is used to show the functional role of the nucleus accumbens in the neurobiological circuit of obsessive compulsive disorder.

Conclusions

So far first results of our ongoing study are very promising. No adverse effects have occurred.