gms | German Medical Science

56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
3èmes journées françaises de Neurochirurgie (SFNC)

Deutsche Gesellschaft für Neurochirurgie e. V.
Société Française de Neurochirurgie

07. bis 11.05.2005, Strasbourg

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Efficacy and safety of alternative embolisation devices in an experimental aneurysm model

Die Effizienz und Sicherheit von alternativen Embolisationsmaterialien in einem experimentellen Aneurysmamodell

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  • corresponding author C. Roth - Abteilung für diagnostische und interventionelle Neuroradiologie, Universitätsklinik des Saarlandes
  • I. Grunwald - Abteilung für diagnostische und interventionelle Neuroradiologie, Universitätsklinik des Saarlandes
  • T. Struffert - Abteilung für diagnostische und interventionelle Neuroradiologie, Universitätsklinik des Saarlandes
  • B. Romeike - Abteilung für Neuropathologie, Universitätsklinik des Saarlandes
  • R. Eymann - Abteilung für Neurochirurgie, Universitätsklinik des Saarlandes
  • W. Reith - Abteilung für diagnostische und interventionelle Neuroradiologie, Universitätsklinik des Saarlandes

Deutsche Gesellschaft für Neurochirurgie. Société Française de Neurochirurgie. 56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC). Strasbourg, 07.-11.05.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc10.05.-13.07

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2005/05dgnc0156.shtml

Published: May 4, 2005

© 2005 Roth et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective

The most commonly used embolization device for intracerebral aneurysms are GDC-Coils. Other embolization devices like Matrix-Coils or the liquid embolization system ONYX(EVOH) are not used in daily routine for the treatment of intracranial aneurysms because they seem to bare more risks like thrombembolic events(ONYX) or harder handling(MATRIX). The aim of the study was to evaluate the efficiacy and safety of both alternative embolization devices under anticoagulation in comparison to GDC-Coils in an experimental aneurysm model in rabbits.

Methods

Aneurysms were induced in the right common carotid artery in rabbits. The animals were devided into 4 groups. Group 1 (n=5) served as a control group, no treatment. The aneurysms in Group 2 (n=10) were occluded with GDC-Coils. In group 3 (n=10) Matrix-Coils were used. In group 4 (n=10) a liquid emoblisation material (ONYX) was used to occlude the aneurysms. All animals received heparine during embolization and aspirine daily until sacrifice. Control angiographies were made after 3 and 6 months. The harvested aneurysms were stained and histologically evaluated.

Results

All aneurysms could be occluded, the control angiographies showed no sign of recanalization. These result were coherent with the histological results. Differences were most striking in the handling of the different materials. Wise the handling of Matrix-Coils is very similar to that of GDC(except for possible increased friction), the handling of Onyx is more demanding. Here a ballon assisted technique including de- and inflatation of the ballon is necessary (risk of ischemic event). The liquid character of the agent might induce more thromboembolic events.

Conclusions

The new embolization devices such as Matrix and Onyx are likely to produce similar good occlusion results. An anticoagulation with heparine/aspirine did not influence the occlusion rate. Thus anticoagulation plays an important part in the prevention of thromboembolic events. In contrast to GDC Coils the handling of Onyx is more demanding and it cannot safely be used in every localization.